Trait: leukocyte count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004308
Description
  • The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Trait category
Hematological measurement
Synonyms 3 synonyms
  • white cell count
  • WBC
  • white blood cell count
Mapped term(s) 3 mapped terms
  • SNOMEDCT:767002
  • MSH:D007958
  • NCIt:C51948

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000113 wbc PGP000051
Xu Y et al. bioRxiv (2020)
Pre
White blood cell count 659 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000113/ScoringFiles/PGS000113.txt.gz
PGS000191 wbc PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
White blood cell count 636 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000191/ScoringFiles/PGS000191.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000258 PGS000113 (wbc) PSS000178 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: White blood cell count Pearson correlation coefficent (r): 0.3655 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000259 PGS000113 (wbc) PSS000152 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: White blood cell count Pearson correlation coefficent (r): 0.3394 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000560 PGS000191 (wbc) PSS000290 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: White blood cell count : 0.06335555804809 sex, age, 10 genetic PCs
PPM000545 PGS000191 (wbc) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: White blood cell count : 0.0867179367384127 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000152 40,466 individuals,
49.0 % Male samples
Mean = 43.84 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000178 81,606 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [38.87, 70.97] years
European UKB
PSS000291 39,260 individuals European INTERVAL