Trait: leukocyte count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004308
Description
  • The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Trait category
Hematological measurement
Synonyms 3 synonyms
  • white cell count
  • WBC
  • white blood cell count
Mapped term(s) 3 mapped terms
  • SNOMEDCT:767002
  • MSH:D007958
  • NCIt:C51948

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000113 wbc PGP000051
Xu Y et al. bioRxiv (2020)
White blood cell count 659 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000113/ScoringFiles/PGS000113.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000258 PGS000113 (wbc) PSS000178 PGP000051
Xu Y et al. (2020)
Reported Trait: White blood cell count Pearson correlation coefficent (r): 0.3655 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000259 PGS000113 (wbc) PSS000152 PGP000051
Xu Y et al. (2020)
Reported Trait: White blood cell count Pearson correlation coefficent (r): 0.3394 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000152 40,466 individuals,
49.0 % Male samples
Mean = 43.84 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000178 81,606 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [38.87, 70.97] years
European UKB