Trait: fasting blood glucose measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004465
Description
  • An fasting blood glucose measurement is a measurement of glucose in the blood of a patient at some defined time point after eating.
Trait category
Other measurement
Synonyms 3 synonyms
  • fasting glucose-related traits
  • fasting blood glucose level
  • fasting plasma glucose
Mapped term(s) SNOMEDCT:271062006
Child trait(s) BMI-adjusted fasting blood glucose measurement

Associated Polygenic Score(s)

Note: This table shows all PGS for "fasting blood glucose measurement" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000305 GRS31_FG PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting glucose fasting blood glucose measurement 31 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000305/ScoringFiles/PGS000305.txt.gz
PGS000306 GRS19_FGadjBMI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting glucose (body mass index adjusted) BMI-adjusted fasting blood glucose measurement 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000306/ScoringFiles/PGS000306.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000776 PGS000306 (GRS19_FGadjBMI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting glucose (mmol/l) : 0.0095 Sex, age, BMI
PPM000775 PGS000305 (GRS31_FG) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting glucose (mmol/l) : 0.0367 Sex, age, age^2

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS