Trait: creatinine measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004518
Description
  • A creatinine measurement is a measure of the metabolite creatinine in a sample. For example, in the serum, where it can be used in assessment of kidney function.
Trait category
Other measurement
Synonyms 3 synonyms
  • creatinine levels
  • serum creatinine levels
  • serum creatinine measurement
Mapped term(s) NCIt:C61023

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000678 snpnet.Creatinine PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Creatinine [umol/L] creatinine measurement 21,027 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000678/ScoringFiles/PGS000678.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001406 PGS000678
(snpnet.Creatinine)
 PSS000667 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — R²: 0.37051
Spearman's ρ: 0.146		 Age, sex, PCs(1-40) —
PPM001441 PGS000678
(snpnet.Creatinine)
 PSS000668 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — R²: 0.44314
Spearman's ρ: 0.229		 Age, sex, PCs(1-40) —
PPM001476 PGS000678
(snpnet.Creatinine)
 PSS000674 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — R²: 0.3939
Spearman's ρ: 0.325		 Age, sex, PCs(1-40) —
PPM001511 PGS000678
(snpnet.Creatinine)
 PSS000675 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — R²: 0.40587
Spearman's ρ: 0.283		 Age, sex, PCs(1-40) —
PPM001546 PGS000678
(snpnet.Creatinine)
 PSS000676 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — R²: 0.41565
Spearman's ρ: 0.337		 Age, sex, PCs(1-40) —
PPM001579 PGS000678
(snpnet.Creatinine)
 PSS000800 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Creatinine [umol/L] — — Spearman's ρ: 0.24 Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000667 — — 6,016 individuals — African unspecified — UKB —
PSS000668 — — 1,081 individuals — East Asian — UKB —
PSS000800 — — 2,129 individuals — European Participants self-identifying as white MESA —
PSS000674 — — 23,576 individuals — European Non-British White UKB —
PSS000675 — — 7,339 individuals — South Asian — UKB —
PSS000676 — — 63,758 individuals — European
(British)		 — UKB —