Trait: urate measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004531
Description
  • A urate measurement is the quantification of some urate in body fluid
Trait category
Other measurement
Synonyms urate levels
Mapped term(s) NCIt:C64814

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000126 Urate_GRS PGP000063 Tin A et al. Nat Genet (2019) Serum urate urate measurement 114 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz
PGS000700 snpnet.Urate PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Urate [umol/L] urate measurement 20,171 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000700/ScoringFiles/PGS000700.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000405 PGS000126
(Urate_GRS)
PSS000233 PGP000063 Tin A et al. (2019) Reported Trait: Prevalent gout cases AUROC: 0.67
PPM000406 PGS000126
(Urate_GRS)
PSS000233 PGP000063 Tin A et al. (2019) Reported Trait: Prevalent gout cases AUROC: 0.84 age, sex
PPM001428 PGS000700
(snpnet.Urate)
PSS000777 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Urate [umol/L] : 0.29536
Spearman's ρ: 0.24
Age, sex, PCs(1-40)
PPM001463 PGS000700
(snpnet.Urate)
PSS000778 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Urate [umol/L] : 0.33805
Spearman's ρ: 0.269
Age, sex, PCs(1-40)
PPM001498 PGS000700
(snpnet.Urate)
PSS000779 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Urate [umol/L] : 0.42054
Spearman's ρ: 0.361
Age, sex, PCs(1-40)
PPM001533 PGS000700
(snpnet.Urate)
PSS000780 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Urate [umol/L] : 0.32468
Spearman's ρ: 0.308
Age, sex, PCs(1-40)
PPM001568 PGS000700
(snpnet.Urate)
PSS000781 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Urate [umol/L] : 0.3966
Spearman's ρ: 0.378
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000777 6,011 individuals African unspecified UKB
PSS000778 1,080 individuals East Asian UKB
PSS000779 23,561 individuals European Non-British White UKB
PSS000780 7,328 individuals South Asian UKB
PSS000781 63,704 individuals European
(British)
UKB
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis.
[
  • 4,908 cases
  • , 329,972 controls
]
European White British subset, unrelated UKB