Trait: urate measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004531
Description
  • A urate measurement is the quantification of some urate in body fluid
Trait category
Other measurement
Synonyms urate levels
Mapped term(s) NCIt:C64814

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000126 Urate_GRS PGP000063
Tin A et al. Nat Genet (2019)
Serum urate 114 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000406 PGS000126 (Urate_GRS) PSS000233 PGP000063
Tin A et al. (2019)
Reported Trait: Prevalent gout cases AUROC: 0.84 age, sex
PPM000405 PGS000126 (Urate_GRS) PSS000233 PGP000063
Tin A et al. (2019)
Reported Trait: Prevalent gout cases AUROC: 0.67

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis.
[
  • 4,908 cases
  • , 329,972 controls
]
European White British subset, unrelated UKB