Trait: serum albumin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004535
Description
  • An albumin measurement is a quantification of albumin in blood. Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Low levels of albumin in the blood may indicate liver disease.
Trait category
Other measurement
Synonyms blood albumin
Mapped term(s) NCIt:C61015

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000669 snpnet.Albumin PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Albumin [g/L] serum albumin measurement 11,912 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000669/ScoringFiles/PGS000669.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001537 PGS000669
(snpnet.Albumin)
 PSS000631 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Albumin [g/L] — — R²: 0.13054
Spearman's ρ: 0.262		 Age, sex, PCs(1-40) —
PPM001502 PGS000669
(snpnet.Albumin)
 PSS000630 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Albumin [g/L] — — R²: 0.15158
Spearman's ρ: 0.216		 Age, sex, PCs(1-40) —
PPM001467 PGS000669
(snpnet.Albumin)
 PSS000629 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Albumin [g/L] — — R²: 0.13257
Spearman's ρ: 0.25		 Age, sex, PCs(1-40) —
PPM001432 PGS000669
(snpnet.Albumin)
 PSS000628 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Albumin [g/L] — — R²: 0.08916
Spearman's ρ: 0.198		 Age, sex, PCs(1-40) —
PPM001397 PGS000669
(snpnet.Albumin)
 PSS000627 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Albumin [g/L] — — R²: 0.10081
Spearman's ρ: 0.121		 Age, sex, PCs(1-40) —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000627 — — 5,573 individuals — African unspecified — UKB —
PSS000628 — — 984 individuals — East Asian — UKB —
PSS000629 — — 21,516 individuals — European Non-British White UKB —
PSS000630 — — 6,687 individuals — South Asian — UKB —
PSS000631 — — 58,196 individuals — European
(British)		 — UKB —