Trait: mean platelet volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004584
Description
  • A measurement of mean platelet volume is a machine-calculated measurement of the average size of platelets found in blood
Trait category
Hematological measurement
Mapped term(s) 2 mapped terms
  • MeSH:D063847
  • MedDRA:10050539

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000104
(mpv)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Mean platelet volume mean platelet volume 681
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000104/ScoringFiles/PGS000104.txt.gz
PGS000179
(mpv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean platelet volume mean platelet volume 654
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000179/ScoringFiles/PGS000179.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000240 PGS000104
(mpv)
PSS000169|
European Ancestry|
78,320 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean platelet volume Pearson correlation coefficent (r): 0.5811 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000241 PGS000104
(mpv)
PSS000143|
European Ancestry|
37,224 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean platelet volume Pearson correlation coefficent (r): 0.5759 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000555 PGS000179
(mpv)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean platelet volume : 0.19379 sex, age, 10 genetic PCs
PPM000535 PGS000179
(mpv)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean platelet volume : 0.27306 sex, age, 10 genetic PCs
PPM001776 PGS000179
(mpv)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Mean platelet volume Pearson correlation coefficent (r): 0.51

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000169 78,320 individuals,
46.0 % Male samples
Mean = 57.26 years
Range = [38.87, 70.99] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS000143 37,224 individuals,
50.0 % Male samples
Mean = 43.8 years
Range = [18.0, 75.7] years
European INTERVAL
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB