Trait: mean platelet volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004584
Description
  • A measurement of mean platelet volume is a machine-calculated measurement of the average size of platelets found in blood
Trait category
Hematological measurement
Mapped term(s) MSH:D063847

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000104 mpv PGP000051
Xu Y et al. bioRxiv (2020)
Pre
Mean platelet volume 681 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000104/ScoringFiles/PGS000104.txt.gz
PGS000179 mpv PGP000078
Vuckovic D et al. medRxiv (2020)
Pre
Mean platelet volume 654 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000179/ScoringFiles/PGS000179.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000240 PGS000104 (mpv) PSS000169 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean platelet volume Pearson correlation coefficent (r): 0.5811 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000241 PGS000104 (mpv) PSS000143 PGP000051
Xu Y et al. (2020)
Pre
Reported Trait: Mean platelet volume Pearson correlation coefficent (r): 0.5759 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000555 PGS000179 (mpv) PSS000290 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean platelet volume : 0.19379488101796 sex, age, 10 genetic PCs
PPM000535 PGS000179 (mpv) PSS000291 PGP000078
Vuckovic D et al. (2020)
Pre
Reported Trait: Mean platelet volume : 0.273060063873527 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000143 37,224 individuals,
50.0 % Male samples
Mean = 43.8 years
Range = [18.0, 75.7] years
European INTERVAL
PSS000169 78,320 individuals,
46.0 % Male samples
Mean = 57.26 years
Range = [38.87, 70.99] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL