Trait: apolipoprotein A 1 measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004614
Description
  • Is a quantification of serum lipoprotein A. Apolipoprotein A-I, encoded in humans by the APOA1 gene and is the major protein component of high density lipoprotein (HDL) in plasma. It is is implicated as a risk factor for atherosclerotic diseases such as coronary heart disease and stroke.
Trait category
Cardiovascular measurement
Inflammatory measurement
Lipid or lipoprotein measurement
Synonyms 2 synonyms
  • Serum amyloid A-1 protein levels
  • lipoprotein A-1 levels

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000671 snpnet.Apolipoprotein_A PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Apolipoprotein A [g/L] apolipoprotein A 1 measurement 19,324 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000671/ScoringFiles/PGS000671.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001399 PGS000671
(snpnet.Apolipoprotein_A)
PSS000637 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] : 0.1486
Spearman's ρ: 0.213
Age, sex, PCs(1-40)
PPM001434 PGS000671
(snpnet.Apolipoprotein_A)
PSS000638 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] : 0.32046
Spearman's ρ: 0.329
Age, sex, PCs(1-40)
PPM001469 PGS000671
(snpnet.Apolipoprotein_A)
PSS000639 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] : 0.31504
Spearman's ρ: 0.385
Age, sex, PCs(1-40)
PPM001504 PGS000671
(snpnet.Apolipoprotein_A)
PSS000640 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] : 0.29281
Spearman's ρ: 0.358
Age, sex, PCs(1-40)
PPM001539 PGS000671
(snpnet.Apolipoprotein_A)
PSS000641 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] : 0.30509
Spearman's ρ: 0.398
Age, sex, PCs(1-40)
PPM001580 PGS000671
(snpnet.Apolipoprotein_A)
PSS000795 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Apolipoprotein A [g/L] Spearman's ρ: 0.241 Age, sex

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000795 1,378 individuals European Participants self-identifying as white MESA
PSS000637 5,550 individuals African unspecified UKB
PSS000638 974 individuals East Asian UKB
PSS000639 21,403 individuals European Non-British White UKB
PSS000640 6,682 individuals South Asian UKB
PSS000641 57,932 individuals European
(British)
UKB