Trait: GFR change measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006829
Description
  • A quantification of the variation in an individual's glomerular filtration rate (GFR) over a period of time used in assessment of kidney function and diagnosis of kidney disease.
Trait category
Other measurement

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000664 GRS7_GFR PGP000124 Gorski M et al. Kidney Int (2020) Rapid decline of glomerular filtration rate (GFR) GFR change measurement 7 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000664/ScoringFiles/PGS000664.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001371 PGS000664 (GRS7_GFR) PSS000600 PGP000124
Gorski M et al. (2020) 		Reported Trait: Rapid decline of glomerular filtration rate estimated from creatinine (CKDi25) — — Odds Ratio (OR, high vs. low risk): 1.29 [1.06, 1.57] Age, sex and baseline eGFRcrea —
PPM001372 PGS000664 (GRS7_GFR) PSS000599 PGP000124
Gorski M et al. (2020) 		Reported Trait: Acute kidney injury — — Odds Ratio (OR, high vs. low risk): 1.2 [1.08, 1.33] Matching variables (age-group and sex), quantitative age —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000600 CKDi25 cases defined as >25% eGFRcrea decline during follow-up together with a movement from eGFRcrea≥60 mL/min/1.73m^2 at baseline to eGFR<60 mL/min/1.73m^2 at follow up compared to CKDi25 controls defined as eGFRcrea≥60 mL/min/1.73m^2. High risk groups had 8-14 adverse alleles. Low risk groups had 0-5 adverse alleles. —
[
  • 448 cases
  • , 10,992 controls
]
 — European — DIACORE, KORA, UKB 87.61% overlap between the CKDi25 GWAS cohort and this dataset.
PSS000599 Cases: ICD 10 code N17. Controls: no ICD10 code N17, frequency-matched by age-group and sex —
[
  • 1,013 cases
  • , 2,434 controls
]
 — European — UKB Possible overlap between GWAS cohorts and this dataset.