Polygenic Score (PGS) ID: PGS004899

Predicted Trait
Reported Trait Spontaneous coronary artery dissection
Mapped Trait(s) spontaneous coronary artery dissection (EFO_0010820)
Released in PGS Catalog: May 8, 2024
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Score Details

Score Construction
PGS Name PRS_SCAD
Development Method
Name LD-pruning
Parameters FDR q value < 0.05, r^2 > 0.2
Variants
Original Genome Build GRCh37
Number of Variants 7
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000629
Citation (link to publication) Saw J et al. Nat Commun (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • East Asian
  • European
5,533 individuals (100%)
PGS Evaluation
European: 75%
Not Reported: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90000582
Europe PMC: 32887874
 5,533 individuals East Asian, European MGI, canSCAD

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021316 PSS011682|
Ancestry Not Reported|
412 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Spontaneous coronary artery dissection OR: 1.82 [1.09, 3.02]
β: 0.597 (0.259)		 — — Age, sex —
PPM021317 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction HR: 0.91 [0.89, 0.93]
β: -0.094 (0.011)		 — — Age, sex, genotyping array and batch, PCs (1-4) —
PPM021318 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction in males HR: 0.91 [0.89, 0.93]
β: -0.092 (0.013)		 — — Age, genotyping array and batch, PCs (1-4) —
PPM021319 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocaridal infarction in females HR: 0.91 [0.87, 0.95]
β: -0.099 (0.022)		 — — Age, genotyping array and batch, PCs (1-4) —
PPM021320 PSS011683|
European Ancestry|
294,465 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Coronary artery disease OR: 0.95 [0.94, 0.96]
β: -0.05 (0.004)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) —
PPM021321 PSS011683|
European Ancestry|
294,465 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Coronary artery disease in males OR: 0.95 [0.94, 0.96]
β: -0.05 (0.004)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) —
PPM021322 PSS011684|
European Ancestry|
314,434 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction OR: 0.96 [0.95, 0.98]
β: -0.04 (0.009)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) —
PPM021323 PSS011684|
European Ancestry|
314,434 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction in males OR: 0.96 [0.95, 0.98]
β: -0.039 (0.009)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011685 MI events were defined pre- enrollment by self-reported medical history and post-enrollment by hospital epi- sode statistics using ICD, Version 10 diagnosis codes (I21, I22, I23, or I24). Events were censored on the date of loss to follow-up, death, or if individuals remained event free up to March 31, 2017. —
[
  • 15,476 cases
  • , 357,580 controls
]
,
45.86 % Male samples
 — European — UKB —
PSS011682 All individuals had multifocal FMD. Cases show those with spontaneous coronary artery dissection. —
[
  • 28 cases
  • , 384 controls
]
 — Not reported — CCGB Cases from Cleveland Clinic FMD Biorepository
PSS011683 An individual was classified as a case if he or she had ≥1 admission to a VA hospital with discharge diagnosis of acute myocardial infarction (AMI) or ≥1 procedure code for revascularization of the coronary arteries or ≥2 ICD codes for CAD (410-414) on ≥2 dates. —
[
  • 95,347 cases
  • , 199,118 controls
]
 — European — MVP —
PSS011684 Cases are individuals with evidence of hospitilisation for myocardial infarction. —
[
  • 14,802 cases
  • , 299,632 controls
]
 — European — MVP —