Polygenic Score (PGS) ID: PGS004900

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: May 8, 2024
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Score Details

Score Construction
PGS Name GRS_BMI_males
Development Method
Name 69 genome-wide significant SNPs associated with body mass index, 25 SNPs associated with pediatric body mass index
Parameters NR
Variants
Original Genome Build NR
Number of Variants 94
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000630
Citation (link to publication) Wu Y et al. PLoS Genet (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals Not reported UKB
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021324 PSS011687|
European Ancestry|
2,690 individuals
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Reported Trait: Body mass index at age 7 in males — — Beta (per quartile increase): 0.61 [0.47, 0.75] — —
PPM021325 PSS011687|
European Ancestry|
2,690 individuals
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Reported Trait: Body mass index at age 18 in males — — Beta (per quartile increase): 1.98 [1.65, 2.32] — —
PPM021328 PSS011687|
European Ancestry|
2,690 individuals
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Reported Trait: Age at adiposity rebound in males — — Beta (median vs. 1st quartile): -0.36 [-0.46, -0.27] — —
PPM021329 PSS011687|
European Ancestry|
2,690 individuals
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Reported Trait: Age at adiposity rebound in males — — Beta (3rd quartile vs. 1st quartile): -0.65 [-0.8, -0.49] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011687 Birth length (crown-heel) was measured by ALSPAC staff who visited newborns soon after birth (median 1 day, range 1-14 days), using a Harpenden Neonatometer (Holtain Ltd). Birth weight was extracted from medical records. From birth to five years, length and weight mea- surements were extracted from health visitor records, which form part of standard childcare in the UK. In this cohort we had up to four measurements taken on average at six weeks and at 10, 21, and 48 months of age. For a random 10% of the cohort, we also have length/height mea- surements from eight research clinic visits, held between the ages of four months and five years of age. From age seven years upwards, all children were invited to annual clinics. In addi- tion, parent-reported child height and weight were also available from the questionnaires. BMI was derived from height and weight measurements (mean 9 measurements per individual) and calculated as the weight (in kg) divided by the square of height (in cm). Mean = 20.0 years 2,690 individuals,
100.0 % Male samples
 — European — ALSPAC —