Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003290
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 48
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003290/ScoringFiles/PGS003290.txt.gz
PGS003641
(L_CA4_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 head volume hippocampal CA4 volume 48
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003641/ScoringFiles/PGS003641.txt.gz
PGS000313
(GRS49_Lp(a))
 PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
 Lipoprotein A lipoprotein A measurement 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000313/ScoringFiles/PGS000313.txt.gz
PGS000489
(PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Breast cancer (female) breast carcinoma 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000489/ScoringFiles/PGS000489.txt.gz
PGS000490
(PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_P_5e-08_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Breast cancer (female) breast carcinoma 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000490/ScoringFiles/PGS000490.txt.gz
PGS000494
(PRSWEB_PHECODE174.1_Onco-iCOGS-ER-negative-BRCA_PT_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Breast cancer (female) breast carcinoma 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000494/ScoringFiles/PGS000494.txt.gz
PGS000569
(PRSWEB_PHECODE185_C3-PROSTATE_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Prostate cancer prostate carcinoma 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000569/ScoringFiles/PGS000569.txt.gz
PGS000733
(PHS46+African)
 PGP000139 |
Karunamuni RA et al. Int J Cancer (2020)
 Prostate cancer prostate carcinoma 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000733/ScoringFiles/PGS000733.txt.gz
PGS002264
(PRS_Combined)
 PGP000293 |
Sharma S et al. Gastroenterology (2022)
 Pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002264/ScoringFiles/PGS002264.txt.gz
PGS003291
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003291/ScoringFiles/PGS003291.txt.gz
PGS003760
(PRS49_EOCRC)
 PGP000480 |
Wang H et al. Genome Med (2023)
 Early onset colorectal cancer colorectal cancer 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003760/ScoringFiles/PGS003760.txt.gz
PGS003837
(height_AFR_CT)
 PGP000489 |
Zhang H et al. Nat Genet (2023)
 Height body height 49
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003837/ScoringFiles/PGS003837.txt.gz
PGS004174
(t1d_4)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Type 1 diabetes type 1 diabetes mellitus 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004174/ScoringFiles/PGS004174.txt.gz
PGS005318
(eGFR_PRS)
 PGP000766 |
Türkmen D et al. Pharmacogenomics J (2024)
 eGFR glomerular filtration rate 49
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005318/ScoringFiles/PGS005318.txt.gz
PGS000011
(GRS50)
 PGP000004 |
Tada H et al. Eur Heart J (2015)
 Coronary artery disease coronary artery disease 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS002246
(Melanoma_PRS50)
 PGP000274 |
Steinberg J et al. Br J Dermatol (2021)
 Melanoma melanoma 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002246/ScoringFiles/PGS002246.txt.gz
PGS003436
(GWAS-sig)
 PGP000438 |
Briggs SEW et al. BMJ (2022)
 Colorectal cancer colorectal cancer 50
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003436/ScoringFiles/PGS003436.txt.gz
PGS004226
(PRS50_T2DEur)
 PGP000526 |
Liu J et al. Nutrients (2023)
 Type 2 diabetes type 2 diabetes mellitus 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004226/ScoringFiles/PGS004226.txt.gz
PGS004284
(GenoBoost_all-cause_dementia_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004284/ScoringFiles/PGS004284.txt.gz
PGS001030
(GBE_HC84)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Pulmonary fibrosis pulmonary fibrosis 51
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001030/ScoringFiles/PGS001030.txt.gz
PGS003342
(CVGRS_ALT)
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Alanine aminotransferase level serum alanine aminotransferase amount 51
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003342/ScoringFiles/PGS003342.txt.gz
PGS004111
(pt_clump.auto.GCST007954.HbA1c)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 HbA1c HbA1c measurement 51
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004111/ScoringFiles/PGS004111.txt.gz
PGS000062
(GRS_TC)
 PGP000045 |
Johnson L et al. PLoS One (2015)
 Total cholesterol total cholesterol measurement 52
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000062/ScoringFiles/PGS000062.txt.gz
PGS000086
(CC_Testis)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Testicular cancer testicular carcinoma,
Testicular Germ Cell Tumor		 52
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000086/ScoringFiles/PGS000086.txt.gz
PGS000796
(CC_Testis_IV)
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Testicular cancer testicular carcinoma,
Testicular Germ Cell Tumor		 52
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000796/ScoringFiles/PGS000796.txt.gz
PGS004952
(PRS52_AMD)
 PGP000673 |
Herold JM et al. Invest Ophthalmol Vis Sci (2023)
 Age-related macular degeneration age-related macular degeneration 52
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004952/ScoringFiles/PGS004952.txt.gz
PGS000047
(BCPRS_ER-)
 PGP000033 |
Kuchenbaecker KB et al. J Natl Cancer Inst (2017)
 Estrogen receptor [ER]-negative breast cancer estrogen-receptor negative breast cancer 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000047/ScoringFiles/PGS000047.txt.gz
PGS000316
(GRS42_Coeliac)
 PGP000093 |
Sharp SA et al. Aliment Pharmacol Ther (2020)
 Coeliac disease celiac disease 53
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000316/ScoringFiles/PGS000316.txt.gz
PGS000362
(PRSWEB_PHECODE149.4_UKBB-SAIGE-HRC-X149.4_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Laryngeal cancer Malignant Laryngeal Neoplasm 53
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000362/ScoringFiles/PGS000362.txt.gz
PGS000877
(uwGRS53_IR)
 PGP000223 |
Lotta LA et al. Nat Genet (2016)
 Insulin resistance Insulin resistance 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000877/ScoringFiles/PGS000877.txt.gz
PGS001013
(GBE_BIN_FC5006148)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Macular degeneration macular degeneration 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001013/ScoringFiles/PGS001013.txt.gz
PGS002536
(repro_ChildLess.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002536/ScoringFiles/PGS002536.txt.gz
PGS000067
(PCa_PHS)
 PGP000047 |
Seibert TM et al. BMJ (2018)
 Prostate cancer prostate carcinoma 54
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000067/ScoringFiles/PGS000067.txt.gz
PGS003343
(CVGRS_AST)
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Aspartate aminotransferase level aspartate aminotransferase measurement 54
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003343/ScoringFiles/PGS003343.txt.gz
PGS000196
(G-PROB_SLE)
 PGP000081 |
Knevel R et al. Sci Transl Med (2020)
 Systemic lupus erythematosus systemic lupus erythematosus 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000196/ScoringFiles/PGS000196.txt.gz
PGS000714
(PRS55_PC)
 PGP000130 |
Sipeky C et al. Sci Rep (2020)
 Prostate cancer prostate carcinoma 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000714/ScoringFiles/PGS000714.txt.gz
PGS005284
(GRS55_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IGA glomerulonephritis 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005284/ScoringFiles/PGS005284.txt.gz
PGS000766
(PRS56_CM)
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Cutaneous melanoma cutaneous melanoma 56
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000766/ScoringFiles/PGS000766.txt.gz
PGS003022
(ExPRSweb_Hypertension_finngen-R4-FG_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertension 56
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003022/ScoringFiles/PGS003022.txt.gz
PGS003336
(CVGRS_FPG)
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Fasting plasma glucose blood glucose amount 56
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003336/ScoringFiles/PGS003336.txt.gz
PGS003352
(ALLGRS_AST)
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Aspartate aminotransferase level aspartate aminotransferase measurement 56
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003352/ScoringFiles/PGS003352.txt.gz
PGS000057
(CHD57)
 PGP000042 |
Natarajan P et al. Circulation (2017)
 Coronary heart disease coronary artery disease 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000057/ScoringFiles/PGS000057.txt.gz
PGS000328
(GRS_SLE)
 PGP000099 |
Reid S et al. Ann Rheum Dis (2019)
 Systemic lupus erythematosus systemic lupus erythematosus 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000328/ScoringFiles/PGS000328.txt.gz
PGS000812
(AD-PRS_57)
 PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
 Alzheimer's disease Alzheimer disease 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000812/ScoringFiles/PGS000812.txt.gz
PGS001251
(GBE_HC1052)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Other interstitial pulmonary diseases (time-to-event) interstitial lung disease 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001251/ScoringFiles/PGS001251.txt.gz
PGS003351
(ALLGRS_ALT)
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Alanine aminotransferase level serum alanine aminotransferase amount 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003351/ScoringFiles/PGS003351.txt.gz
PGS003618
(L_CA1_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 head volume hippocampal CA1 volume 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003618/ScoringFiles/PGS003618.txt.gz
PGS003745
(PRS57_SM)
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Skin Melanoma cutaneous melanoma 57
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003745/ScoringFiles/PGS003745.txt.gz
PGS003762
(PRS57_amyloid)
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Amyloid beta 42 beta-amyloid 1-42 measurement 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003762/ScoringFiles/PGS003762.txt.gz
PGS003960
(GRS57_SLE)
 PGP000509 |
Barnado A et al. Arthritis Rheumatol (2023)
 Systemic lupus erythematosus systemic lupus erythematosus 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003960/ScoringFiles/PGS003960.txt.gz
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