Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005259
(thyroid_cancer_mixed_prscs)
 PGP000748 |
White SL et al. medRxiv (2025)
|Pre		 Thyroid carcenoma thyroid gland carcinoma 1,085,173
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005259/ScoringFiles/PGS005259.txt.gz
PGS005258
(thyroid_cancer_mixed_pt)
 PGP000748 |
White SL et al. medRxiv (2025)
|Pre		 Thyroid carcenoma thyroid gland carcinoma 84
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005258/ScoringFiles/PGS005258.txt.gz
PGS005257
(aortic_valve_area)
 PGP000747 |
Kany S et al. Nat Genet (2025)
 Aortic valve area aortic measurement 1,111,632
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005257/ScoringFiles/PGS005257.txt.gz
PGS005256
(peak_velocity)
 PGP000747 |
Kany S et al. Nat Genet (2025)
 Peak aortic velocity aortic stenosis,
aortic measurement		 1,111,632
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005256/ScoringFiles/PGS005256.txt.gz
PGS005255
(mean_gradient)
 PGP000747 |
Kany S et al. Nat Genet (2025)
 Mean pressure gradient aortic stenosis,
aortic measurement		 1,111,632
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005255/ScoringFiles/PGS005255.txt.gz
PGS005254
(aortic_stenosis)
 PGP000747 |
Kany S et al. Nat Genet (2025)
 Aortic stenosis aortic stenosis 1,110,912
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005254/ScoringFiles/PGS005254.txt.gz
PGS005253
(CVD_MetaPRS)
 PGP000746 |
Sun D et al. Genome Med (2025)
 Cardiovascular disease cardiovascular disorder 3,846,195
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005253/ScoringFiles/PGS005253.txt.gz
PGS005252
(IAVGC_AS_PRS)
 PGP000745 |
Small AM et al. Nat Genet (2025)
 Aortic stenosis aortic stenosis 1,119,377
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005252/ScoringFiles/PGS005252.txt.gz
PGS005251
(iPRS)
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 INFLA-Score platelet count,
C-reactive protein measurement,
neutrophil-to-lymphocyte ratio,
leukocyte quantity		 1,113
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005251/ScoringFiles/PGS005251.txt.gz
PGS005250
(PGS14_QBB_14SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005250/ScoringFiles/PGS005250.txt.gz
PGS005249
(PGS5_QBB_6SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005249/ScoringFiles/PGS005249.txt.gz
PGS005248
(PGS4_QBB_9SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 9
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005248/ScoringFiles/PGS005248.txt.gz
PGS005247
(T2D_PRS_PRS_CSx_META_F_SAS)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,126,657
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005247/ScoringFiles/PGS005247.txt.gz
PGS005246
(T2D_PRS_PRS_CSx_META_F_EUR)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,111,848
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005246/ScoringFiles/PGS005246.txt.gz
PGS005245
(T2D_PRS_PRS_CSx_META_F_EAS)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,021,829
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005245/ScoringFiles/PGS005245.txt.gz
PGS005244
(T2D_PRS_PRS_CSx_META_F_AMR)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 960,470
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005244/ScoringFiles/PGS005244.txt.gz
PGS005243
(T2D_PRS_PRS_CSx_META_F_AFR)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,183,017
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005243/ScoringFiles/PGS005243.txt.gz
PGS005242
(T2D_PRS_PRS_CSx_META_T)
 PGP000742 |
Guo B G et al. Nat Commun (2025)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,257,036
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005242/ScoringFiles/PGS005242.txt.gz
PGS005241
(SBayesRC)
 PGP000741 |
Tanha HM et al. HGG Adv (2025)
 Prostate carcinoma prostate carcinoma 3,802,635
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005241/ScoringFiles/PGS005241.txt.gz
PGS005240
(SBayesR)
 PGP000741 |
Tanha HM et al. HGG Adv (2025)
 Prostate carcinoma prostate carcinoma 904,103
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005240/ScoringFiles/PGS005240.txt.gz
PGS005239
(PRS-CS)
 PGP000741 |
Tanha HM et al. HGG Adv (2025)
 Prostate carcinoma prostate carcinoma 943,048
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005239/ScoringFiles/PGS005239.txt.gz
PGS005238
(LDpred2)
 PGP000741 |
Tanha HM et al. HGG Adv (2025)
 Prostate carcinoma prostate carcinoma 964,607
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005238/ScoringFiles/PGS005238.txt.gz
PGS005237
(SCT)
 PGP000741 |
Tanha HM et al. HGG Adv (2025)
 Prostate carcinoma prostate carcinoma 517,551
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005237/ScoringFiles/PGS005237.txt.gz
PGS005236
(CAD_AnnoPred)
 PGP000740 |
Hu J et al. PLoS Comput Biol (2025)
 Coronary artery disease coronary artery disorder 2,994,055
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005236/ScoringFiles/PGS005236.txt.gz
PGS005235
(F4_Adiposity)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Adiposity obesity disorder 709,828
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005235/ScoringFiles/PGS005235.txt.gz
PGS005234
(F3_Body_Size_and_Adipose_Distribution)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Body size and adipose distribution body weight,
body fat distribution		 709,193
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005234/ScoringFiles/PGS005234.txt.gz
PGS005233
(F2_Abdominal_Size)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Abdominal size body fat distribution 710,487
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005233/ScoringFiles/PGS005233.txt.gz
PGS005232
(F1_Birth_Size)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Birth size birth weight 710,799
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005232/ScoringFiles/PGS005232.txt.gz
PGS005231
(GRS142_CAD)
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Coronary artery disease coronary artery disorder 142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005231/ScoringFiles/PGS005231.txt.gz
PGS005230
(PRS71_STROKE)
 PGP000736 |
Ma Y et al. Stroke (2023)
 Stroke stroke disorder 71
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005230/ScoringFiles/PGS005230.txt.gz
PGS005229
(FFS_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Fried Frailty Score frailty measurement 2,761,868
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005229/ScoringFiles/PGS005229.txt.gz
PGS005228
(FI_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Frailty Index frailty measurement 2,379,429
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005228/ScoringFiles/PGS005228.txt.gz
PGS005227
(F6_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 6 (disability) of frailty frailty measurement 1,726,064
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005227/ScoringFiles/PGS005227.txt.gz
PGS005226
(F5_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 5 (poorer cognition) of frailty frailty measurement 1,715,891
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005226/ScoringFiles/PGS005226.txt.gz
PGS005225
(F4_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 4 (metabolic/respiratory problems) of frailty frailty measurement 710,413
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005225/ScoringFiles/PGS005225.txt.gz
PGS005224
(F3_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 3 (multimorbidity) of frailty frailty measurement 1,588,232
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005224/ScoringFiles/PGS005224.txt.gz
PGS005223
(F2_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 2 (unhealthy lifestyle) of frailty frailty measurement 1,719,220
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005223/ScoringFiles/PGS005223.txt.gz
PGS005222
(F1_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 Factor 1 (social isolation) of frailty frailty measurement 1,727,299
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005222/ScoringFiles/PGS005222.txt.gz
PGS005221
(General_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2025)
 General factor of frailty frailty measurement 943,126
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005221/ScoringFiles/PGS005221.txt.gz
PGS005220
(PRS_BMIunadjOSA)
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Obstructive sleep apnea (UnadjustedBMI) obstructive sleep apnea syndrome 984,184
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005220/ScoringFiles/PGS005220.txt.gz
PGS005219
(PRS_BMIadjOSA)
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Obstructive sleep apnea (AdjustedBMI) obstructive sleep apnea syndrome 982,740
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005219/ScoringFiles/PGS005219.txt.gz
PGS005218
(prsweights_hypothyroidism_excl23)
 PGP000733 |
Rand SA et al. Nat Genet (2025)
 Hypothyroidism hypothyroidism 1,110,091
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005218/ScoringFiles/PGS005218.txt.gz
PGS005217
(PRS_PAD)
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Peripheral artery disease peripheral arterial disease 1,296,292
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005217/ScoringFiles/PGS005217.txt.gz
PGS005216
(drinks_per_week)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Drinks per week alcohol consumption quality 221,689
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005216/ScoringFiles/PGS005216.txt.gz
PGS005215
(addiction_rf)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Addiction risk factors substance-related disorder 11,627
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005215/ScoringFiles/PGS005215.txt.gz
PGS005214
(PAU)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Problematic alcohol use alcohol use disorder measurement 453,914
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005214/ScoringFiles/PGS005214.txt.gz
PGS005213
(AUD)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder by DSM-V alcohol use disorder measurement 336,813
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005213/ScoringFiles/PGS005213.txt.gz
PGS005212
(AUDIT_P)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder (7-item problematic use index) alcohol use disorder measurement 384,933
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005212/ScoringFiles/PGS005212.txt.gz
PGS005211
(AUDIT_C)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder (3-item consumption index) alcohol use disorder measurement 2,338,199
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005211/ScoringFiles/PGS005211.txt.gz
PGS005210
(Thyroid_PRS)
 PGP000729 |
Gibson TM et al. Nat Med (2024)
 Thyroid cancer thyroid gland carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005210/ScoringFiles/PGS005210.txt.gz
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