Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002088
(portability-ldpred2_714.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Rheumatoid arthritis rheumatoid arthritis 95,083
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002088/ScoringFiles/PGS002088.txt.gz
PGS002491
(disease_DIABETES_ANY_DIAGNOSED.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Diabetes (any type) diabetes mellitus 95,066
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002491/ScoringFiles/PGS002491.txt.gz
PGS002498
(biochemistry_Glucose.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Glucose glucose measurement 95,023
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002498/ScoringFiles/PGS002498.txt.gz
PGS018654
(TPMI_241_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic nodular goiter toxic multinodular goitre 94,850
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018654/ScoringFiles/PGS018654.txt.gz
PGS019604
(TPMI_695.42_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Systemic lupus erythematosus systemic lupus erythematosus 93,987
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019604/ScoringFiles/PGS019604.txt.gz
PGS019598
(TPMI_695.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Lupus localized and systemic systemic lupus erythematosus 93,337
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019598/ScoringFiles/PGS019598.txt.gz
PGS002494
(disease_ENDOCRINE_DIABETES.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Endocrine and diabetes diseases diabetes mellitus,
endocrine system disorder		 93,293
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002494/ScoringFiles/PGS002494.txt.gz
PGS002517
(disease_RESPIRATORY_ENT.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Respiratory and ear-nose-throat diseases respiratory system disorder 93,256
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002517/ScoringFiles/PGS002517.txt.gz
PGS018649
(TPMI_240_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Simple and unspecified goiter goiter 92,760
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018649/ScoringFiles/PGS018649.txt.gz
PGS002236
(PRS_AsAoD)
 PGP000268 |
Tcheandjieu C et al. Nat Genet (2022)
 Ascending aorta diameter (MRI-derived) aortic measurement 92,299
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002236/ScoringFiles/PGS002236.txt.gz
PGS019896
(TPMI_HR_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Heart rate heart rate 91,181
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019896/ScoringFiles/PGS019896.txt.gz
PGS018576
(TPMI_191_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 90,905
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018576/ScoringFiles/PGS018576.txt.gz
PGS002504
(disease_HI_CHOL_SELF_REP.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 High cholesterol Hypercholesterolemia 90,341
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002504/ScoringFiles/PGS002504.txt.gz
PGS001887
(portability-PLR_ankle_spacing)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ankle spacing width anthropometric measurement 89,827
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001887/ScoringFiles/PGS001887.txt.gz
PGS002479
(repro_NumberChildrenEverBorn_Pooled.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Number of children ever born number of children ever born measurement 89,453
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002479/ScoringFiles/PGS002479.txt.gz
PGS003292
(ExPRSweb_CysC_CKDGen-1000Genomes-DiscoveryMeta-eGFRcys_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 88,980
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003292/ScoringFiles/PGS003292.txt.gz
PGS003156
(ExPRSweb_VitB12_100013-irnt_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 88,908
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003156/ScoringFiles/PGS003156.txt.gz
PGS004016
(lassosum.CV.GCST008059.CKD)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Chronic kidney disease (CKD) chronic kidney disease 88,605
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004016/ScoringFiles/PGS004016.txt.gz
PGS004017
(lassosum.CV.GCST008059.eGFR)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 eGFR glomerular filtration rate 88,605
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004017/ScoringFiles/PGS004017.txt.gz
PGS002482
(disease_AID_ALL.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Autoimmune disease autoimmune disease 88,404
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002482/ScoringFiles/PGS002482.txt.gz
PGS002490
(disease_DERMATOLOGY.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Dermatologic diseases skin disorder 88,324
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002490/ScoringFiles/PGS002490.txt.gz
PGS003650
(R_hippocampal_fissure_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right hippocampal fissure volume hippocampal fissure volume 88,296
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003650/ScoringFiles/PGS003650.txt.gz
PGS000361
(PRSWEB_PHECODE149.4_C3-LARYNX_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Laryngeal cancer larynx cancer 87,893
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000361/ScoringFiles/PGS000361.txt.gz
PGS019893
(TPMI_HCT_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hematocrit hematocrit 87,889
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019893/ScoringFiles/PGS019893.txt.gz
PGS003274
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Creatine) glomerular filtration rate,
creatine level		 87,693
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003274/ScoringFiles/PGS003274.txt.gz
PGS001960
(portability-PLR_log_IGF1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 IGF-1 IGF-1 measurement 87,149
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001960/ScoringFiles/PGS001960.txt.gz
PGS003259
(ExPRSweb_Creatine_eGFRcrea-overall-IV-2GC_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Creatine) glomerular filtration rate,
creatine level		 87,064
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003259/ScoringFiles/PGS003259.txt.gz
PGS019151
(TPMI_401.21_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 86,725
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019151/ScoringFiles/PGS019151.txt.gz
PGS002487
(repro_ChildLess.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 86,054
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002487/ScoringFiles/PGS002487.txt.gz
PGS001954
(portability-PLR_log_HDL)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 HDL cholesterol high density lipoprotein cholesterol measurement 85,429
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001954/ScoringFiles/PGS001954.txt.gz
PGS001922
(portability-PLR_FVC)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Forced vital capacity (FVC), Best measure vital capacity 85,349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001922/ScoringFiles/PGS001922.txt.gz
PGS019146
(TPMI_401.3_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other hypertensive complications hypertensive disorder 84,636
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019146/ScoringFiles/PGS019146.txt.gz
PGS001947
(portability-PLR_log_cystatinC)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Cystatin C cystatin C measurement 84,459
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001947/ScoringFiles/PGS001947.txt.gz
PGS018900
(TPMI_290.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dementia dementia 84,318
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018900/ScoringFiles/PGS018900.txt.gz
PGS003637
(L_CA4_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 head volume hippocampal CA4 volume 84,284
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003637/ScoringFiles/PGS003637.txt.gz
PGS003000
(ExPRSweb_Hypertension_20002-1072_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertensive disorder 83,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003000/ScoringFiles/PGS003000.txt.gz
PGS019892
(TPMI_HbA1c_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Glycated hemoglobin HbA1c measurement 83,746
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019892/ScoringFiles/PGS019892.txt.gz
PGS003160
(ExPRSweb_VitB12_100013-raw_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 83,714
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003160/ScoringFiles/PGS003160.txt.gz
PGS018537
(TPMI_174.11_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Malignant neoplasm of female breast female breast carcinoma 83,711
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018537/ScoringFiles/PGS018537.txt.gz
PGS003603
(L_HATA_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left hippocampus-amygdala transition area volume hippocampal amigdala transition area volume 83,449
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003603/ScoringFiles/PGS003603.txt.gz
PGS003721
(R_subiculum_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right subiculum body volume subiculum volume 83,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003721/ScoringFiles/PGS003721.txt.gz
PGS001909
(portability-PLR_erythrocyte)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Red blood cell (erythrocyte) count erythrocyte count 81,887
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001909/ScoringFiles/PGS001909.txt.gz
PGS003001
(ExPRSweb_Hypertension_20002-1072_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertensive disorder 81,218
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003001/ScoringFiles/PGS003001.txt.gz
PGS019475
(TPMI_594_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urinary calculus urinary volume 81,176
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019475/ScoringFiles/PGS019475.txt.gz
PGS018742
(TPMI_250.7_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diabetic retinopathy diabetic retinopathy 80,280
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018742/ScoringFiles/PGS018742.txt.gz
PGS001962
(portability-PLR_log_leukocyte)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 White blood cell (leukocyte) count leukocyte quantity 80,228
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001962/ScoringFiles/PGS001962.txt.gz
PGS018882
(TPMI_282_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hereditary hemolytic anemias familial hemolytic anemia 80,045
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018882/ScoringFiles/PGS018882.txt.gz
PGS018532
(TPMI_174.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Breast cancer female breast cancer 79,735
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018532/ScoringFiles/PGS018532.txt.gz
PGS003674
(R_hippocampal_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right hippocampal head volume hippocampal volume 79,660
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003674/ScoringFiles/PGS003674.txt.gz
PGS003706
(R_presubiculum_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right presubiculum body volume presubiculum volume 79,285
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003706/ScoringFiles/PGS003706.txt.gz
Showing 3551 to 3600 of 6972 rows