Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019442
(TPMI_585.33_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic Kidney Disease Stage III chronic kidney disease 245,933
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019442/ScoringFiles/PGS019442.txt.gz
PGS018976
(TPMI_327.41_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 246,776
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018976/ScoringFiles/PGS018976.txt.gz
PGS002638
(disease_DIABETES_ANY_DIAGNOSED.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Diabetes (any type) diabetes mellitus 247,386
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002638/ScoringFiles/PGS002638.txt.gz
PGS002249
(AD_PRS_0.5)
 PGP000276 |
Lourida I et al. JAMA (2019)
 Alzheimer's disease Alzheimer disease 249,273
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz
PGS018426
(TPMI_070.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 253,455
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018426/ScoringFiles/PGS018426.txt.gz
PGS018476
(TPMI_150_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Esophageal cancer esophageal cancer 255,880
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018476/ScoringFiles/PGS018476.txt.gz
PGS019290
(TPMI_497_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 255,924
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019290/ScoringFiles/PGS019290.txt.gz
PGS019057
(TPMI_370_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 256,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019057/ScoringFiles/PGS019057.txt.gz
PGS002641
(disease_ENDOCRINE_DIABETES.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Endocrine and diabetes diseases diabetes mellitus,
endocrine system disorder		 256,678
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002641/ScoringFiles/PGS002641.txt.gz
PGS018982
(TPMI_331_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other cerebral degenerations Cerebral degeneration 256,810
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018982/ScoringFiles/PGS018982.txt.gz
PGS002671
(disease_T2D.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 258,382
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002671/ScoringFiles/PGS002671.txt.gz
PGS018556
(TPMI_182_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Malignant neoplasm of uterus tumor of uterus 260,113
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018556/ScoringFiles/PGS018556.txt.gz
PGS002502
(body_HEIGHTz.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Height body height 262,080
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002502/ScoringFiles/PGS002502.txt.gz
PGS018857
(TPMI_279_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders involving the immune mechanism Immunodeficiency 262,507
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018857/ScoringFiles/PGS018857.txt.gz
PGS002232
(STLFRQPGS)
 PGP000265 |
Bonfiglio F et al. Cell Genom (2021)
 Stool Frequency bowel opening frequency 263,279
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002232/ScoringFiles/PGS002232.txt.gz
PGS003164
(ExPRSweb_VitB12_Wood-et-al-2013-1000G_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 263,612
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003164/ScoringFiles/PGS003164.txt.gz
PGS000320
(PRS_BMI)
 PGP000096 |
Chami N et al. PLoS Med (2020)
 Body mass index (BMI) body mass index 263,640
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000320/ScoringFiles/PGS000320.txt.gz
PGS005399
(T1D_PRS_male)
 PGP000781 |
Qu HQ et al. Diabetes Res Clin Pract (2026)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 264,227
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005399/ScoringFiles/PGS005399.txt.gz
PGS003094
(ExPRSweb_T2D_29358691-GCST005413_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 266,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003094/ScoringFiles/PGS003094.txt.gz
PGS019454
(TPMI_586.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cyst of kidney acquired Simple Cyst of Kidney 268,992
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019454/ScoringFiles/PGS019454.txt.gz
PGS018626
(TPMI_218.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Uterine leiomyoma uterine corpus leiomyoma 270,998
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018626/ScoringFiles/PGS018626.txt.gz
PGS018932
(TPMI_292.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mild cognitive impairment Cognitive impairment 271,015
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018932/ScoringFiles/PGS018932.txt.gz
PGS019635
(TPMI_706.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 273,955
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019635/ScoringFiles/PGS019635.txt.gz
PGS002654
(biochemistry_LDLdirect.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 LDL cholesterol low density lipoprotein cholesterol measurement 274,585
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002654/ScoringFiles/PGS002654.txt.gz
PGS002110
(portability-ldpred2_darker_skin0)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Skin color Abnormal skin pigmentation 275,831
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002110/ScoringFiles/PGS002110.txt.gz
PGS018661
(TPMI_241.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 275,929
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018661/ScoringFiles/PGS018661.txt.gz
PGS019291
(TPMI_497_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 275,948
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019291/ScoringFiles/PGS019291.txt.gz
PGS019578
(TPMI_686.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Carbuncle and furuncle carbuncle,
Furuncle		 277,466
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019578/ScoringFiles/PGS019578.txt.gz
PGS004685
(height_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 279,186
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004685/ScoringFiles/PGS004685.txt.gz
PGS002023
(portability-ldpred2_242)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Thyrotoxicosis with or without goiter thyrotoxicosis 279,385
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002023/ScoringFiles/PGS002023.txt.gz
PGS002979
(ExPRSweb_Height_ieu-a-89_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Height body height 280,347
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002979/ScoringFiles/PGS002979.txt.gz
PGS018546
(TPMI_180.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cervical cancer cervical cancer 280,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018546/ScoringFiles/PGS018546.txt.gz
PGS003129
(ExPRSweb_Thinness_STILTS-UKHLS_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Thinness body mass index 281,336
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003129/ScoringFiles/PGS003129.txt.gz
PGS002989
(ExPRSweb_Height_ieu-a-89_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Height body height 282,132
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002989/ScoringFiles/PGS002989.txt.gz
PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 283,128
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002661/ScoringFiles/PGS002661.txt.gz
PGS000512
(PRSWEB_PHECODE174.1_Onco-iCOGS-Overall-BRCA_LASSOSUM_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Breast cancer (female) breast carcinoma 286,144
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000512/ScoringFiles/PGS000512.txt.gz
PGS018835
(TPMI_277_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other disorders of metabolism metabolic disease 287,237
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018835/ScoringFiles/PGS018835.txt.gz
PGS019437
(TPMI_585.32_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 289,757
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019437/ScoringFiles/PGS019437.txt.gz
PGS004625
(HDL_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004625/ScoringFiles/PGS004625.txt.gz
PGS004630
(HDL_EAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004630/ScoringFiles/PGS004630.txt.gz
PGS004635
(HDL_SAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004635/ScoringFiles/PGS004635.txt.gz
PGS003169
(ExPRSweb_VitB12_Wood-et-al-2013-1000G_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 291,530
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003169/ScoringFiles/PGS003169.txt.gz
PGS019206
(TPMI_427.6_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 292,424
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019206/ScoringFiles/PGS019206.txt.gz
PGS019673
(TPMI_715.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Ankylosing spondylitis ankylosing spondylitis 292,554
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019673/ScoringFiles/PGS019673.txt.gz
PGS019758
(TPMI_790.6_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 292,919
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019758/ScoringFiles/PGS019758.txt.gz
PGS000754
(PRS_SLE)
 PGP000160 |
Wang YF et al. Nat Commun (2021)
 Systemic lupus erythematosus systemic lupus erythematosus 293,684
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000754/ScoringFiles/PGS000754.txt.gz
PGS003014
(ExPRSweb_Hypertension_I10_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertensive disorder 294,142
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003014/ScoringFiles/PGS003014.txt.gz
PGS019668
(TPMI_715_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 294,406
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019668/ScoringFiles/PGS019668.txt.gz
PGS019468
(TPMI_593.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Microscopic hematuria Microscopic hematuria 294,454
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019468/ScoringFiles/PGS019468.txt.gz
PGS019067
(TPMI_379_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other disorders of eye eye disorder 295,490
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019067/ScoringFiles/PGS019067.txt.gz
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