Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004906
(PRS60_TSH)
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Thyroid stimulating hormone concentration thyroid stimulating hormone amount 60
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004906/ScoringFiles/PGS004906.txt.gz
PGS004907
(PRS31_FT4)
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Free thyroxine concentration thyroxine amount 31
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004907/ScoringFiles/PGS004907.txt.gz
PGS004905
(PRS155_AF)
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Atrial fibrillation atrial fibrillation 155
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004905/ScoringFiles/PGS004905.txt.gz
PGS004904
(PRS127_CRC)
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Colorectal cancer colorectal carcinoma 127
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004904/ScoringFiles/PGS004904.txt.gz
PGS004903
(PRS_ALL)
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Atopic dermatitis atopic eczema 38
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004903/ScoringFiles/PGS004903.txt.gz
PGS004902
(PRSBMI)
 PGP000631 |
Chikowore T et al. Genome Med (2024)
 Body mass index (BMI) body mass index 322,639
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004902/ScoringFiles/PGS004902.txt.gz
PGS004900
(GRS_BMI_males)
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Body mass index (BMI) body mass index 94
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004900/ScoringFiles/PGS004900.txt.gz
PGS004901
(GRS_BMI_females)
 PGP000630 |
Wu Y et al. PLoS Genet (2020)
 Body mass index (BMI) body mass index 94
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004901/ScoringFiles/PGS004901.txt.gz
PGS004899
(PRS_SCAD)
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Spontaneous coronary artery dissection spontaneous coronary artery dissection 7
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004899/ScoringFiles/PGS004899.txt.gz
PGS004898
(PRS_AD)
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Alzheimer's disease Alzheimer disease 44
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004898/ScoringFiles/PGS004898.txt.gz
PGS004896
(mAlb)
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Microalbuminuria Moderate albuminuria 29
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004896/ScoringFiles/PGS004896.txt.gz
PGS004897
(UACR)
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Urinary albumin-to-creatinine ratio urinary albumin to creatinine ratio 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004897/ScoringFiles/PGS004897.txt.gz
PGS004893
(overall.hybrid.prs)
 PGP000621 |
Gao G et al. Hum Mol Genet (2022)
 Breast cancer breast carcinoma 56,943
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004893/ScoringFiles/PGS004893.txt.gz
PGS004894
(ERpos.prs)
 PGP000621 |
Gao G et al. Hum Mol Genet (2022)
 Estrogen receptor positive breast cancer estrogen-receptor positive breast cancer 29,309
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004894/ScoringFiles/PGS004894.txt.gz
PGS004895
(ERneg.prs)
 PGP000621 |
Gao G et al. Hum Mol Genet (2022)
 Estrogen receptor negative breast cancer estrogen-receptor negative breast cancer 28,405
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004895/ScoringFiles/PGS004895.txt.gz
PGS004890
(CC-GWAS_PRS)
 PGP000620 |
Sun X et al. Cancer Res (2024)
 Triple negative breast cancer versus luminal breast cancer triple-negative breast cancer 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004890/ScoringFiles/PGS004890.txt.gz
PGS004891
(TNBC_PRS25)
 PGP000620 |
Sun X et al. Cancer Res (2024)
 Triple negative breast cancer triple-negative breast cancer 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004891/ScoringFiles/PGS004891.txt.gz
PGS004892
(TNBC_PRS41)
 PGP000620 |
Sun X et al. Cancer Res (2024)
 Triple negative breast cancer triple-negative breast cancer 41
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004892/ScoringFiles/PGS004892.txt.gz
PGS004887
(T2D_gePGS)
 PGP000619 |
Mandla R et al. Genome Med (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,117,628
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004887/ScoringFiles/PGS004887.txt.gz
PGS004888
(CAD_gePGS)
 PGP000619 |
Mandla R et al. Genome Med (2024)
 Coronary artery diseae coronary artery disease 1,110,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004888/ScoringFiles/PGS004888.txt.gz
PGS004889
(CKD_gePGS)
 PGP000619 |
Mandla R et al. Genome Med (2024)
 Chronic kidney disease chronic kidney disease 1,117,375
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004889/ScoringFiles/PGS004889.txt.gz
PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Breast cancer breast carcinoma 872,060
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004869/ScoringFiles/PGS004869.txt.gz
PGS004870
(INTERVENE_MegaPRS_T2D)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 930,506
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004870/ScoringFiles/PGS004870.txt.gz
PGS004871
(INTERVENE_MegaPRS_Gout)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Gout gout 762,621
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004871/ScoringFiles/PGS004871.txt.gz
PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Prostate cancer prostate carcinoma 765,876
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004872/ScoringFiles/PGS004872.txt.gz
PGS004873
(INTERVENE_MegaPRS_RA)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 551,074
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004873/ScoringFiles/PGS004873.txt.gz
PGS004874
(INTERVENE_MegaPRS_T1D)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 56,916
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004874/ScoringFiles/PGS004874.txt.gz
PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 All Cancers cancer 818,872
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004875/ScoringFiles/PGS004875.txt.gz
PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Appendicitis appendicitis 601,835
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004876/ScoringFiles/PGS004876.txt.gz
PGS004877
(INTERVENE_MegaPRS_Asthma)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Asthma asthma 870,454
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004877/ScoringFiles/PGS004877.txt.gz
PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 785,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004878/ScoringFiles/PGS004878.txt.gz
PGS004879
(INTERVENE_MegaPRS_CHD)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Coronary heart disease coronary artery disease 610,677
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004879/ScoringFiles/PGS004879.txt.gz
PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 843,248
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004880/ScoringFiles/PGS004880.txt.gz
PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Epilepsy epilepsy 605,432
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004881/ScoringFiles/PGS004881.txt.gz
PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Hip osteoarthritis osteoarthritis, hip 773,587
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004882/ScoringFiles/PGS004882.txt.gz
PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Knee osteoarthritis osteoarthritis, knee 952,133
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004883/ScoringFiles/PGS004883.txt.gz
PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Lung cancer lung carcinoma 655,479
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004884/ScoringFiles/PGS004884.txt.gz
PGS004885
(INTERVENE_MegaPRS_MDD)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Major depressive disorder major depressive disorder 801,544
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004885/ScoringFiles/PGS004885.txt.gz
PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Melanoma melanoma 692,834
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004886/ScoringFiles/PGS004886.txt.gz
PGS004868
(T2DPGS)
 PGP000617 |
Yun JS et al. Cardiovasc Diabetol (2022)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 6,580,804
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004868/ScoringFiles/PGS004868.txt.gz
PGS004865
(PRS105_BC)
 PGP000612 |
Gao C et al. J Clin Oncol (2021)
 Breast cancer breast carcinoma 105
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004865/ScoringFiles/PGS004865.txt.gz
PGS004866
(PRS105_ERposBC)
 PGP000612 |
Gao C et al. J Clin Oncol (2021)
 ER-positive breast cancer estrogen-receptor positive breast cancer 105
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004866/ScoringFiles/PGS004866.txt.gz
PGS004867
(PRS105_ERnegBC)
 PGP000612 |
Gao C et al. J Clin Oncol (2021)
 ER-negative breast cancer estrogen-receptor negative breast cancer 105
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004867/ScoringFiles/PGS004867.txt.gz
PGS004864
(PRS186_BMI)
 PGP000611 |
de Toro-Martín J et al. JCI Insight (2018)
 Body mass index (BMI) body mass index 186
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004864/ScoringFiles/PGS004864.txt.gz
PGS004863
(PRS74_AD)
 PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
 Alzheimer's disease Alzheimer disease 74
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004863/ScoringFiles/PGS004863.txt.gz
PGS004861
(hermes.gwama)
 PGP000608 |
Zheng SL et al. medRxiv (2023)
|Pre		 Dilated cardiomyopathy dilated cardiomyopathy 713,932
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004861/ScoringFiles/PGS004861.txt.gz
PGS004862
(hermes.mtag)
 PGP000608 |
Zheng SL et al. medRxiv (2023)
|Pre		 Dilated cardiomyopathy (MTAG) dilated cardiomyopathy 709,534
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004862/ScoringFiles/PGS004862.txt.gz
PGS004860
(Genome-wide-PRS)
 PGP000607 |
Boumtje V et al. EBioMedicine (2024)
 Lung cancer lung carcinoma 1,143,554
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004860/ScoringFiles/PGS004860.txt.gz
PGS004859
(T2D_PRS_CS)
 PGP000605 |
Deutsch AJ et al. Diabetes Care (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,108,235
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004859/ScoringFiles/PGS004859.txt.gz
PGS004701
(a1c_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 HbA1c HbA1c measurement 1,107,927
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004701/ScoringFiles/PGS004701.txt.gz
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