Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019192
(TPMI_427.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 593,905
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019192/ScoringFiles/PGS019192.txt.gz
PGS004771
(Hct_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Hematocrit hematocrit 594,293
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004771/ScoringFiles/PGS004771.txt.gz
PGS003317
(ExPRSweb_CysC_eGFRcys-overall-IV-2GC_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Cystatin C) cystatin C measurement,
glomerular filtration rate		 594,334
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003317/ScoringFiles/PGS003317.txt.gz
PGS019439
(TPMI_585.32_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 594,737
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019439/ScoringFiles/PGS019439.txt.gz
PGS004805
(Neutrophils_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Neutrophil count neutrophil count 595,488
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004805/ScoringFiles/PGS004805.txt.gz
PGS003054
(ExPRSweb_Smoking_20160_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Smoking status smoking status measurement 595,975
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003054/ScoringFiles/PGS003054.txt.gz
PGS002055
(portability-ldpred2_443.9)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Peripheral vascular disease, unspecified peripheral vascular disease 599,514
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002055/ScoringFiles/PGS002055.txt.gz
PGS002053
(portability-ldpred2_433)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Cerebrovascular disease cerebrovascular disorder 599,726
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002053/ScoringFiles/PGS002053.txt.gz
PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Appendicitis appendicitis 601,835
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004876/ScoringFiles/PGS004876.txt.gz
PGS003387
(best_ESCA_BEEA)
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Esophageal adenocarcinoma or Barrett’s esophagus esophageal adenocarcinoma,
Barrett esophagus		 601,980
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003387/ScoringFiles/PGS003387.txt.gz
PGS002170
(portability-ldpred2_log_glucose)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Glucose glucose measurement 602,241
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002170/ScoringFiles/PGS002170.txt.gz
PGS004066
(megaprs.CV.GCST002783.BMI)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Body mass index (BMI) body mass index 602,445
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004066/ScoringFiles/PGS004066.txt.gz
PGS002059
(portability-ldpred2_459.9)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Circulatory disease NEC vascular disorder 604,572
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002059/ScoringFiles/PGS002059.txt.gz
PGS000133
(SCZ_BVU)
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Schizophrenia schizophrenia 604,645
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000133/ScoringFiles/PGS000133.txt.gz
PGS018452
(TPMI_110.13_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 605,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018452/ScoringFiles/PGS018452.txt.gz
PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Epilepsy epilepsy 605,432
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004881/ScoringFiles/PGS004881.txt.gz
PGS018788
(TPMI_272_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of lipoid metabolism metabolic disease 607,470
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018788/ScoringFiles/PGS018788.txt.gz
PGS004747
(creatinine_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Serum creatinine serum creatinine amount 609,027
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004747/ScoringFiles/PGS004747.txt.gz
PGS004050
(megaprs.auto.GCST002783.BMI)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Body mass index (BMI) body mass index 609,706
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004050/ScoringFiles/PGS004050.txt.gz
PGS004879
(INTERVENE_MegaPRS_CHD)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Coronary heart disease coronary artery disorder 610,677
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004879/ScoringFiles/PGS004879.txt.gz
PGS002121
(portability-ldpred2_ECG_RR_interval)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 RR interval RR interval 616,710
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002121/ScoringFiles/PGS002121.txt.gz
PGS018918
(TPMI_291_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other specified nonpsychotic and or transient mental disorders mental disorder 616,739
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018918/ScoringFiles/PGS018918.txt.gz
PGS003433
(LDPred2-grid-sp)
 PGP000438 |
Briggs SEW et al. BMJ (2022)
 Colorectal cancer colorectal cancer 616,956
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003433/ScoringFiles/PGS003433.txt.gz
PGS019863
(TPMI_BMI_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Body mass index (BMI) body mass index 618,331
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019863/ScoringFiles/PGS019863.txt.gz
PGS019287
(TPMI_495.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 619,851
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019287/ScoringFiles/PGS019287.txt.gz
PGS018793
(TPMI_272.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 620,040
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018793/ScoringFiles/PGS018793.txt.gz
PGS002630
(body_BMIz.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Body mass index (BMI) body mass index 620,484
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002630/ScoringFiles/PGS002630.txt.gz
PGS002076
(portability-ldpred2_600)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hyperplasia of prostate benign prostatic hyperplasia 627,341
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002076/ScoringFiles/PGS002076.txt.gz
PGS002227
(portability-ldpred2_sphered_cell_volume)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean sphered cell volume hematological measurement 630,576
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002227/ScoringFiles/PGS002227.txt.gz
PGS019868
(TPMI_HbA1c_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Glycated hemoglobin HbA1c measurement 632,423
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019868/ScoringFiles/PGS019868.txt.gz
PGS002024
(portability-ldpred2_244)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hypothyroidism hypothyroidism 632,597
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002024/ScoringFiles/PGS002024.txt.gz
PGS002215
(portability-ldpred2_no_sex)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Age first had sexual intercourse age at first sexual intercourse measurement 633,660
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002215/ScoringFiles/PGS002215.txt.gz
PGS019876
(TPMI_PP_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pulse pressure pulse pressure measurement 634,124
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019876/ScoringFiles/PGS019876.txt.gz
PGS004711
(ALP_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Alkaline phosphatase alkaline phosphatase measurement 634,277
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004711/ScoringFiles/PGS004711.txt.gz
PGS003244
(ExPRSweb_Creatine_30700-raw_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Creatine creatine level 638,561
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003244/ScoringFiles/PGS003244.txt.gz
PGS002081
(portability-ldpred2_681)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Superficial cellulitis and abscess cellulitis 640,921
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002081/ScoringFiles/PGS002081.txt.gz
PGS002186
(portability-ldpred2_log_monocyte)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Monocyte count monocyte count 641,455
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002186/ScoringFiles/PGS002186.txt.gz
PGS003059
(ExPRSweb_Smoking_SmokingInitiation_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Smoking status smoking status measurement 641,463
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003059/ScoringFiles/PGS003059.txt.gz
PGS003064
(ExPRSweb_Smoking_SmokingInitiation_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Smoking status smoking status measurement 642,068
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003064/ScoringFiles/PGS003064.txt.gz
PGS002051
(portability-ldpred2_428)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Congestive heart failure; nonhypertensive congestive heart failure 642,241
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002051/ScoringFiles/PGS002051.txt.gz
PGS005330
(T2D_PRS_SAS)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 642,349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005330/ScoringFiles/PGS005330.txt.gz
PGS019235
(TPMI_433.3_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral ischemia Cerebral ischemia 645,233
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019235/ScoringFiles/PGS019235.txt.gz
PGS005398
(T1D_PRS_combined)
 PGP000781 |
Qu HQ et al. Diabetes Res Clin Pract (2026)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 645,391
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005398/ScoringFiles/PGS005398.txt.gz
PGS002013
(portability-ldpred2_153)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Colorectal cancer colorectal cancer 648,559
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002013/ScoringFiles/PGS002013.txt.gz
PGS002130
(portability-ldpred2_F_log_testosterone)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Testosterone (female only) testosterone measurement,
female		 650,195
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002130/ScoringFiles/PGS002130.txt.gz
PGS002195
(portability-ldpred2_log_SHBG)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sex hormone binding globulin (SHBG) sex hormone-binding globulin measurement 650,364
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002195/ScoringFiles/PGS002195.txt.gz
PGS018913
(TPMI_290.13_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Senile dementia dementia 652,894
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018913/ScoringFiles/PGS018913.txt.gz
PGS005323
(PRS_CS_IPF)
 PGP000769 |
Zhu J et al. Am J Respir Crit Care Med (2025)
 Idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis 653,482
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005323/ScoringFiles/PGS005323.txt.gz
PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Lung cancer lung carcinoma 655,479
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004884/ScoringFiles/PGS004884.txt.gz
PGS002095
(portability-ldpred2_743.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Osteoporosis osteoporosis 658,775
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002095/ScoringFiles/PGS002095.txt.gz
Showing 4151 to 4200 of 6972 rows