PGS Publication: PGP000242

Publication Information (EuropePMC)
Title A polygenic risk score for asthma in a large racially diverse population.
PubMed ID 34459047(Europe PMC)
doi 10.1111/cea.14007
Publication Date Aug. 30, 2021
Journal Clin Exp Allergy
Author(s) Sordillo JE, Lutz SM, Jorgenson E, Iribarren C, McGeachie M, Dahlin A, Tantisira K, Kelly R, Lasky-Su J, Sakornsakolpat P, Moll M, Cho MH, Wu AC.
Released in PGS Catalog: Oct. 7, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000917
(PRS_asthma_lasso_primary_afr)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 1,353,838
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000917/ScoringFiles/PGS000917.txt.gz
PGS000919
(PRS_asthma_lasso_primary_his)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 1,173,854
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000919/ScoringFiles/PGS000919.txt.gz
PGS000915
(PRS_asthma_standard)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 41
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000915/ScoringFiles/PGS000915.txt.gz
PGS000918
(PRS_asthma_lasso_primary_eur)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 1,117,220
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000918/ScoringFiles/PGS000918.txt.gz
PGS000916
(PRS_asthma_lasso_primary_as)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 1,379,334
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000916/ScoringFiles/PGS000916.txt.gz
PGS000920
(PRS_asthma_lasso_secondary)
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Asthma asthma 405,088
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000920/ScoringFiles/PGS000920.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002985 PGS000915
(PRS_asthma_standard)
PSS001454|
European Ancestry|
51,478 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.16 [1.14, 1.18] AUROC: 0.54 Age, sex, body mass index
PPM002986 PGS000915
(PRS_asthma_standard)
PSS001455|
Hispanic or Latin American Ancestry|
4,405 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.12 [1.05, 1.19] AUROC: 0.53 Age, sex, body mass index
PPM002984 PGS000915
(PRS_asthma_standard)
PSS001453|
Additional Asian Ancestries|
5,152 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.1 [1.04, 1.17] AUROC: 0.52 Age, sex, body mass index
PPM002987 PGS000915
(PRS_asthma_standard)
PSS001452|
African Ancestry|
2,070 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.05 [0.97, 1.15] AUROC: 0.51 Age, sex, body mass index
PPM002988 PGS000916
(PRS_asthma_lasso_primary_as)
PSS001453|
Additional Asian Ancestries|
5,152 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.18 [1.1, 1.27] AUROC: 0.54 Age, sex, body mass index
PPM002989 PGS000918
(PRS_asthma_lasso_primary_eur)
PSS001454|
European Ancestry|
51,478 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.2 [1.18, 1.23] AUROC: 0.55 Age, sex, body mass index
PPM002990 PGS000919
(PRS_asthma_lasso_primary_his)
PSS001455|
Hispanic or Latin American Ancestry|
4,405 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.17 [1.1, 1.26] AUROC: 0.55 Age, sex, body mass index
PPM002991 PGS000917
(PRS_asthma_lasso_primary_afr)
PSS001452|
African Ancestry|
2,070 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.1 [0.99, 1.22] AUROC: 0.53 Age, sex, body mass index
PPM002992 PGS000920
(PRS_asthma_lasso_secondary)
PSS001454|
European Ancestry|
51,478 individuals
PGP000242 |
Sordillo JE et al. Clin Exp Allergy (2021)
Reported Trait: Asthma OR: 1.28 [1.25, 1.31] AUROC: 0.5724 Age, sex, body mass index

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001452 Cases were individuals with asthma. Asthma cases were defined as subjects with one or more of the following electronic medical record entries: physician-diagnosed asthma, self-reported asthma or a report of an asthma exacerbation (hospitalization, ICU/emergency department visit due to asthma). 2,070 individuals African unspecified GERA
PSS001453 Cases were individuals with asthma. Asthma cases were defined as subjects with one or more of the following electronic medical record entries: physician-diagnosed asthma, self-reported asthma or a report of an asthma exacerbation (hospitalization, ICU/emergency department visit due to asthma). 5,152 individuals Asian unspecified GERA
PSS001454 Cases were individuals with asthma. Asthma cases were defined as subjects with one or more of the following electronic medical record entries: physician-diagnosed asthma, self-reported asthma or a report of an asthma exacerbation (hospitalization, ICU/emergency department visit due to asthma). 51,478 individuals European GERA
PSS001455 Cases were individuals with asthma. Asthma cases were defined as subjects with one or more of the following electronic medical record entries: physician-diagnosed asthma, self-reported asthma or a report of an asthma exacerbation (hospitalization, ICU/emergency department visit due to asthma). 4,405 individuals Hispanic or Latin American GERA