| Publication Information (EuropePMC) | |
| Title | Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. |
| PubMed ID | 42237039(Europe PMC) |
| doi | 10.1038/s41588-026-02583-1 |
| Publication Date | June 3, 2026 |
| Journal | Nat Genet |
| Author(s) | EADB, EADI, Bonn, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO, PGC-ALZ. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS005389 (ADRD_consensus_main_score) |
PGP000776 | EADB et al. Nat Genet (2026) |
Alzheimer's disease | Alzheimer disease | 115 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005389/ScoringFiles/PGS005389.txt.gz | |
| PGS005390 (ADRD_consensus_no_proxy_score) |
PGP000776 | EADB et al. Nat Genet (2026) |
Alzheimer's disease | Alzheimer disease | 91 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005390/ScoringFiles/PGS005390.txt.gz | |
| PGS005391 (ADRD_consensus_no_biobank_score) |
PGP000776 | EADB et al. Nat Genet (2026) |
Alzheimer's disease | Alzheimer disease | 65 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005391/ScoringFiles/PGS005391.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM023429 | PGS005390 (ADRD_consensus_no_proxy_score) |
PSS012178| European Ancestry| 5,793 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: Braak NFT Stage at death | OR: 1.11 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
| PPM023430 | PGS005391 (ADRD_consensus_no_biobank_score) |
PSS012178| European Ancestry| 5,793 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: Braak NFT Stage at death | OR: 1.13 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
| PPM023431 | PGS005389 (ADRD_consensus_main_score) |
PSS012179| European Ancestry| 5,800 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: CERAD score at death | OR: 1.12 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
| PPM023432 | PGS005390 (ADRD_consensus_no_proxy_score) |
PSS012179| European Ancestry| 5,800 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: CERAD score at death | OR: 1.12 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
| PPM023433 | PGS005391 (ADRD_consensus_no_biobank_score) |
PSS012179| European Ancestry| 5,800 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: CERAD score at death | OR: 1.14 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
| PPM023428 | PGS005389 (ADRD_consensus_main_score) |
PSS012178| European Ancestry| 5,793 individuals |
PGP000776 | EADB et al. Nat Genet (2026) |
Reported Trait: Braak NFT Stage at death | OR: 1.11 | — | — | age at death, sex, the number of APOE ε4 and ε2 alleles, 10 PCs and centers | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012178 | Braak NFT Stage | — | [
|
— | European | — | NACC | — |
| PSS012179 | CERAD score | — | [
|
— | European | — | NACC | — |