PGS Sample Set (PSS): PSS000332

Phenotype CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410
Sample Ancestry African American or Afro-Caribbean

Sample Numbers

Total number
7,070 individuals
Detailed numbers
311 cases (4.4%)
6,759 controls
31.0% Male samples
Participant Follow-up Time
  • Median : 9.2 years
  • Iqr : [5.5, 13.0] years
Age of Study Participants
  • Mean : 43.6 years
  • Sd : 12.5 years
Number of Cohort(s) 7
Sample distribution
Sample gender distribution

Cohort(s)

Cohort Short Name Cohort Full Name Previous/other/additional names (e.g. sub-cohorts)
BioMe BioMe® BioBank Program (Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai) BioMe Biobank (BMBB), MT. SINAI BioMe Biobank Platform (IMP), Charles R Bronfman Institute for Personalized Medicine - IPM / BioBank Genome Wide Association Study of Cardiovascular, Renal and Metabolic Phenotypes (IPM), Charles R Bronfman Institute for Personalized Medicine - IPM / BioBank Genome Wide Association Study of Cardiovascular, Renal and Metabolic Phenotypes I (IPM I), Charles R Bronfman Institute for Personalized Medicine - IPM / BioBank Genome Wide Association Study of Cardiovascular, Renal and Metabolic Phenotypes II (IPM II), IPM_EA_Affy, IPM_EA_Illu, Mount Sinai BioMe BioBank (Mount Sinai)
BioVU BioVU, the Vanderbilt DNA Databank project
Columbia Columbia University Medical Center
eMERGE Medical Records and Genomics study
KP Kaiser Permanente
Nugene NUgene (Northwestern University)
PHB Partners HealthCare Biobank

Additional information

right censored at age 75 years or at the age of last observation (whichever was first)