PGS Sample Set (PSS): PSS001071

Phenotype All individuals had non-small cell lung cancer (NSCLC) and were receiving immune checkpoint inhibitor (CPI) therapy. Cases were individuals who had experienced immune-related thyroid dysfunction following CPI therapy. A thyroid event after the start of CPI therapy was defined as either (1) incident hypothyroidism or (2) transient incident hyperthyroidism followed by incident hypothyroidism. Incident hypothyroidism was defined as (a) a TSH of ≥ 10 mU/L or (b) TSH of ≥ 5 mU/L with a new prescription of levothyroxine ≥ 50 mcg. Incident hyperthyroidism was defined as TSH < 0.05 mU/L.
Sample Ancestry European

Sample Numbers

Total number
634 individuals
Number of Cohort(s) 1


Cohort Short Name Cohort Full Name Previous/other/additional names (e.g. sub-cohorts)
MSKCC Memorial Sloan Kettering Cancer Center

Additional information

Additional cases and controls were obtained from the Vanderbilt University Medical Centre (VUMC)