Predicted Trait | |
Reported Trait | Body Mass Index |
Mapped Trait(s) | body mass index (EFO_0004340) |
Score Construction | |
PGS Name | GPS_BMI |
Development Method | |
Name | LDpred |
Parameters | ρ = 0.03; LD reference panel = 503 European samples from 1000 Genomes phase 3 |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 2,100,302 |
Effect Weight Type | NR |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000017 |
Citation (link to publication) | Khera AV et al. Cell (2019) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
1,276 individuals | Hispanic or Latin American | NR |
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
236,781 individuals | European | NR |
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
887 individuals | African American or Afro-Caribbean | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 119,951 individuals | European | UKB | — | — | — | — | UKB Phase 1 |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000054 | PSS000037| European Ancestry| 288,016 individuals |
PGP000017 | Khera AV et al. Cell (2019) |
Reported Trait: Body mass index | β: 1.41 | — | R²: 0.08526 | First 10 genetic PCs | Beta is in units of kg/m^2 |
PPM001725 | PSS000885| European Ancestry| 19,588 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between male siblings | OR: 2.21 [1.92, 2.54] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001726 | PSS000886| European Ancestry| 21,499 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within female siblings | OR: 2.09 [1.74, 2.51] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001727 | PSS000886| European Ancestry| 21,499 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between female siblings | OR: 2.13 [1.87, 2.43] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001728 | PSS000887| European Ancestry| 26,323 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within male siblings | OR: 2.15 [1.91, 2.41] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001730 | PSS000888| European Ancestry| 29,527 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within female siblings | OR: 1.87 [1.68, 2.09] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001731 | PSS000888| European Ancestry| 29,527 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between female siblings | OR: 2.05 [1.89, 2.22] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001732 | PSS000889| European Ancestry| 21,187 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within male siblings | OR: 2.0 [1.79, 2.23] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001733 | PSS000889| European Ancestry| 21,187 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between male siblings | OR: 2.12 [1.96, 2.3] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001734 | PSS000890| European Ancestry| 25,096 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within female siblings | OR: 2.0 [1.8, 2.21] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001735 | PSS000890| European Ancestry| 25,096 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between female siblings | OR: 2.03 [1.88, 2.19] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001736 | PSS000891| European Ancestry| 14,487 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within male siblings | OR: 1.9 [1.68, 2.14] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001769 | PSS000911| Greater Middle Eastern Ancestry| 13,989 individuals |
PGP000147 | Thareja G et al. Nat Commun (2021) |Ext. |
Reported Trait: Body mass index | — | — | Pearson correlation coefficent (r): 0.22 | — | — |
PPM001737 | PSS000891| European Ancestry| 14,487 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between male siblings | OR: 2.0 [1.83, 2.19] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001738 | PSS000892| European Ancestry| 17,740 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within female siblings | OR: 1.72 [1.53, 1.93] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001739 | PSS000892| European Ancestry| 17,740 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between female siblings | OR: 1.89 [1.74, 2.05] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001724 | PSS000885| European Ancestry| 19,588 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity within male siblings | OR: 2.02 [1.66, 2.46] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PPM001729 | PSS000887| European Ancestry| 26,323 individuals |
PGP000141 | Brandkvist M et al. PLoS Med (2020) |Ext. |
Reported Trait: Obesity between male siblings | OR: 2.15 [1.97, 2.34] | — | — | Sex, time of measurement, age, PCs (1-20), genotyping batch | 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019). |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000892 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
0.0 % Male samples |
Mean = 58.9 years Sd = 11.9 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000890 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
0.0 % Male samples |
Mean = 51.2 years Sd = 15.0 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000911 | — | — | 13,989 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
PSS000885 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
100.0 % Male samples |
Mean = 42.4 years Sd = 12.6 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000886 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
0.0 % Male samples |
Mean = 42.6 years Sd = 12.8 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000887 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
100.0 % Male samples |
Mean = 47.6 years Sd = 16.1 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000888 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
0.0 % Male samples |
Mean = 47.1 years Sd = 16.5 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000889 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
100.0 % Male samples |
Mean = 52.3 years Sd = 14.5 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |
PSS000037 | — | — | 288,016 individuals, 45.0 % Male samples |
— | European | — | UKB | — |
PSS000891 | Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. | — | [ ,
100.0 % Male samples |
Mean = 60.2 years Sd = 11.5 years |
European | — | HUNT | number o cases = number of observations (more than 1 pp) |