Trait: bone density

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003923
Description The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Trait category
Other measurement
Synonyms 8 synonyms
  • BMD
  • Bone Densities
  • Bone Mineral Densities
  • Bone Mineral Density
  • Density, Bone
  • Density, Bone Mineral
  • aBMD
  • areal bone mineral density
Mapped terms 3 mapped terms
  • ICD10:M85
  • MeSH:D015519
  • NCIt:C96950
Child trait(s) heel bone mineral density

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "bone density" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000121
(2018_BMD62_GRS.FN)
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Bone mineral density (BMD) bone density 62
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000121/ScoringFiles/PGS000121.txt.gz
PGS000122
(2018_BMD33_GRS.FN)
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Bone mineral density (BMD) bone density 33
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000122/ScoringFiles/PGS000122.txt.gz
PGS001037
(GBE_INI78)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Heel bone mineral density (BMD) T-score, automated heel bone mineral density 14,310
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001037/ScoringFiles/PGS001037.txt.gz
PGS001038
(GBE_INI4106)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Left heel bone mineral density (BMD) T-score, automated heel bone mineral density 9,275
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001038/ScoringFiles/PGS001038.txt.gz
PGS001039
(GBE_INI4125)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Right heel bone mineral density (BMD) T-score, automated heel bone mineral density 9,753
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001039/ScoringFiles/PGS001039.txt.gz
PGS001402
(GBE_INI3148)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Heel bone mineral density (BMD) heel bone mineral density 14,251
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001402/ScoringFiles/PGS001402.txt.gz
PGS001403
(GBE_INI4105)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Heel bone mineral density (BMD) (L) heel bone mineral density 8,285
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001403/ScoringFiles/PGS001403.txt.gz
PGS001404
(GBE_INI4124)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Heel bone mineral density (BMD) (R) heel bone mineral density 9,637
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001404/ScoringFiles/PGS001404.txt.gz
PGS001955
(portability-PLR_log_heel_BMD)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Heel bone mineral density (BMD) heel bone mineral density 73,565
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001955/ScoringFiles/PGS001955.txt.gz
PGS002173
(portability-ldpred2_log_heel_BMD)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Heel bone mineral density (BMD) heel bone mineral density 729,074
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002173/ScoringFiles/PGS002173.txt.gz
PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002315/ScoringFiles/PGS002315.txt.gz
PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 25,831
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002387/ScoringFiles/PGS002387.txt.gz
PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 53,472
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002436/ScoringFiles/PGS002436.txt.gz
PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 171,392
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002485/ScoringFiles/PGS002485.txt.gz
PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 11,440
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002534/ScoringFiles/PGS002534.txt.gz
PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 7,908
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002583/ScoringFiles/PGS002583.txt.gz
PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 432,286
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002632/ScoringFiles/PGS002632.txt.gz
PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone Mineral Density bone density 984,276
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002681/ScoringFiles/PGS002681.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000368 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.25 [1.02, 1.56] Age
PPM000378 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.41 [1.01, 1.96] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000377 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.5 [1.08, 2.09] Age, sex, prior fracture or fall
PPM000376 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.48 [1.07, 2.06] Age
PPM000370 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.14 [0.92, 1.42] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000369 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.24 [1.0, 1.54] Age, sex, prior fracture or fall
PPM000362 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.03 [0.77, 1.36] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000361 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.19 [0.91, 1.57] Age, sex, prior fracture or fall
PPM000360 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.21 [0.91, 1.59] Age
PPM000354 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.13 [0.98, 1.29] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000353 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.18 [1.03, 1.36] Age, sex, prior fracture or fall
PPM000352 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.19 [1.03, 1.37] Age
PPM000367 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.28 [1.02, 1.59]
PPM000359 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.23 [0.92, 1.63]
PPM000351 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.2 [1.04, 1.38]
PPM000350 PGS000121
(2018_BMD62_GRS.FN)
PSS000212|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Lumbar spine BMD β: -0.037 (0.007)
PPM000349 PGS000121
(2018_BMD62_GRS.FN)
PSS000212|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Femoral neck BMD β: -0.019 (0.004)
PPM000375 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.51 [1.08, 2.1]
PPM000381 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.6 [1.06, 2.4] Age, sex, prior fracture or fall
PPM000380 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.62 [1.08, 2.43] Age
PPM000374 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.28 [0.97, 1.68] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000373 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.35 [1.03, 1.78] Age, sex, prior fracture or fall
PPM000382 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.53 [1.01, 2.31] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000372 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.36 [1.04, 1.78] Age
PPM000366 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.01 [0.65, 1.35] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000365 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.06 [0.74, 1.51] Age, sex, prior fracture or fall
PPM000364 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.11 [0.78, 1.57] Age
PPM000358 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.23 [1.02, 1.46] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000357 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.24 [1.04, 1.47] Age, sex, prior fracture or fall
PPM000356 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.26 [1.06, 1.5] Age
PPM000371 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.39 [1.06, 1.82]
PPM000363 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.09 [0.77, 1.54]
PPM000355 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.26 [1.06, 1.5]
PPM000379 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.65 [1.09, 2.48]
PPM007945 PGS001037
(GBE_INI78)
PSS007478|
European Ancestry|
12,376 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated : 0.1881 [0.17936, 0.19685]
Incremental R2 (full-covars): 0.13506
PGS R2 (no covariates): 0.13678 [0.12885, 0.14471]
age, sex, UKB array type, Genotype PCs
PPM007943 PGS001037
(GBE_INI78)
PSS007476|
African Ancestry|
2,253 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated : 0.0346 [0.02587, 0.04333]
Incremental R2 (full-covars): 0.01755
PGS R2 (no covariates): 0.01827 [0.01182, 0.02472]
age, sex, UKB array type, Genotype PCs
PPM007944 PGS001037
(GBE_INI78)
PSS007477|
East Asian Ancestry|
795 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated Incremental R2 (full-covars): 0.06623
: 0.09833 [0.07154, 0.12513]
PGS R2 (no covariates): 0.06929 [0.04608, 0.09251]
age, sex, UKB array type, Genotype PCs
PPM007946 PGS001037
(GBE_INI78)
PSS007479|
South Asian Ancestry|
2,312 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated : 0.10193 [0.08923, 0.11462]
Incremental R2 (full-covars): 0.06757
PGS R2 (no covariates): 0.07119 [0.06021, 0.08216]
age, sex, UKB array type, Genotype PCs
PPM007947 PGS001037
(GBE_INI78)
PSS007480|
European Ancestry|
38,834 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated : 0.19661 [0.19123, 0.20198]
Incremental R2 (full-covars): 0.1419
PGS R2 (no covariates): 0.14159 [0.13671, 0.14646]
age, sex, UKB array type, Genotype PCs
PPM007948 PGS001038
(GBE_INI4106)
PSS007296|
African Ancestry|
3,560 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) : 0.02571 [0.01812, 0.03331]
Incremental R2 (full-covars): 0.00529
PGS R2 (no covariates): 0.00688 [0.00288, 0.01089]
age, sex, UKB array type, Genotype PCs
PPM007949 PGS001038
(GBE_INI4106)
PSS007297|
East Asian Ancestry|
781 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) : 0.10298 [0.0757, 0.13026]
Incremental R2 (full-covars): 0.08297
PGS R2 (no covariates): 0.082 [0.05709, 0.10691]
age, sex, UKB array type, Genotype PCs
PPM007950 PGS001038
(GBE_INI4106)
PSS007298|
European Ancestry|
10,636 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) : 0.17491 [0.16634, 0.18348]
Incremental R2 (full-covars): 0.11202
PGS R2 (no covariates): 0.11274 [0.10534, 0.12014]
age, sex, UKB array type, Genotype PCs
PPM007951 PGS001038
(GBE_INI4106)
PSS007299|
South Asian Ancestry|
5,043 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) : 0.08123 [0.06963, 0.09282]
Incremental R2 (full-covars): 0.05296
PGS R2 (no covariates): 0.05415 [0.04441, 0.0639]
age, sex, UKB array type, Genotype PCs
PPM007952 PGS001038
(GBE_INI4106)
PSS007300|
European Ancestry|
25,716 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) : 0.17984 [0.17459, 0.18509]
Incremental R2 (full-covars): 0.11708
PGS R2 (no covariates): 0.11589 [0.11134, 0.12043]
age, sex, UKB array type, Genotype PCs
PPM007953 PGS001039
(GBE_INI4125)
PSS007326|
African Ancestry|
3,592 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) : 0.02463 [0.01719, 0.03207]
Incremental R2 (full-covars): 0.00616
PGS R2 (no covariates): 0.00698 [0.00294, 0.01101]
age, sex, UKB array type, Genotype PCs
PPM007954 PGS001039
(GBE_INI4125)
PSS007327|
East Asian Ancestry|
782 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) : 0.09885 [0.072, 0.1257]
Incremental R2 (full-covars): 0.07541
PGS R2 (no covariates): 0.07555 [0.05147, 0.09963]
age, sex, UKB array type, Genotype PCs
PPM007955 PGS001039
(GBE_INI4125)
PSS007328|
European Ancestry|
10,633 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) : 0.1752 [0.16663, 0.18378]
Incremental R2 (full-covars): 0.11145
PGS R2 (no covariates): 0.11271 [0.10531, 0.12011]
age, sex, UKB array type, Genotype PCs
PPM007956 PGS001039
(GBE_INI4125)
PSS007329|
South Asian Ancestry|
5,041 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) : 0.08262 [0.07095, 0.0943]
Incremental R2 (full-covars): 0.05817
PGS R2 (no covariates): 0.05815 [0.0481, 0.06821]
age, sex, UKB array type, Genotype PCs
PPM007957 PGS001039
(GBE_INI4125)
PSS007330|
European Ancestry|
25,728 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) : 0.19359 [0.18823, 0.19894]
Incremental R2 (full-covars): 0.1242
PGS R2 (no covariates): 0.12266 [0.11802, 0.1273]
age, sex, UKB array type, Genotype PCs
PPM007080 PGS001402
(GBE_INI3148)
PSS007241|
African Ancestry|
2,248 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) : 0.03461 [0.02588, 0.04334]
Incremental R2 (full-covars): 0.01792
PGS R2 (no covariates): 0.01849 [0.012, 0.02498]
age, sex, UKB array type, Genotype PCs
PPM007081 PGS001402
(GBE_INI3148)
PSS007242|
East Asian Ancestry|
794 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) : 0.0956 [0.0691, 0.1221]
Incremental R2 (full-covars): 0.06421
PGS R2 (no covariates): 0.06783 [0.04482, 0.09083]
age, sex, UKB array type, Genotype PCs
PPM007082 PGS001402
(GBE_INI3148)
PSS007243|
European Ancestry|
12,374 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) : 0.18897 [0.18022, 0.19773]
Incremental R2 (full-covars): 0.13548
PGS R2 (no covariates): 0.13714 [0.1292, 0.14508]
age, sex, UKB array type, Genotype PCs
PPM007083 PGS001402
(GBE_INI3148)
PSS007244|
South Asian Ancestry|
2,310 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) : 0.10415 [0.09135, 0.11695]
Incremental R2 (full-covars): 0.06926
PGS R2 (no covariates): 0.07321 [0.06211, 0.08432]
age, sex, UKB array type, Genotype PCs
PPM007084 PGS001402
(GBE_INI3148)
PSS007245|
European Ancestry|
38,814 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) : 0.19926 [0.19386, 0.20465]
Incremental R2 (full-covars): 0.14341
PGS R2 (no covariates): 0.14309 [0.1382, 0.14798]
age, sex, UKB array type, Genotype PCs
PPM007100 PGS001403
(GBE_INI4105)
PSS007291|
African Ancestry|
3,558 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (L) : 0.02599 [0.01836, 0.03363]
Incremental R2 (full-covars): 0.00518
PGS R2 (no covariates): 0.00667 [0.00273, 0.01062]
age, sex, UKB array type, Genotype PCs
PPM007101 PGS001403
(GBE_INI4105)
PSS007292|
East Asian Ancestry|
781 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (L) : 0.10653 [0.07889, 0.13417]
Incremental R2 (full-covars): 0.08652
PGS R2 (no covariates): 0.08516 [0.05986, 0.11046]
age, sex, UKB array type, Genotype PCs
PPM007102 PGS001403
(GBE_INI4105)
PSS007293|
European Ancestry|
10,626 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (L) : 0.17743 [0.16883, 0.18604]
Incremental R2 (full-covars): 0.11194
PGS R2 (no covariates): 0.11269 [0.10529, 0.12009]
age, sex, UKB array type, Genotype PCs
PPM007103 PGS001403
(GBE_INI4105)
PSS007294|
South Asian Ancestry|
5,037 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (L) : 0.08239 [0.07073, 0.09405]
Incremental R2 (full-covars): 0.05357
PGS R2 (no covariates): 0.05487 [0.04506, 0.06467]
age, sex, UKB array type, Genotype PCs
PPM007104 PGS001403
(GBE_INI4105)
PSS007295|
European Ancestry|
25,706 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (L) : 0.18131 [0.17605, 0.18657]
Incremental R2 (full-covars): 0.11744
PGS R2 (no covariates): 0.11656 [0.11201, 0.12112]
age, sex, UKB array type, Genotype PCs
PPM007110 PGS001404
(GBE_INI4124)
PSS007321|
African Ancestry|
3,586 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (R) : 0.02449 [0.01707, 0.03191]
Incremental R2 (full-covars): 0.00554
PGS R2 (no covariates): 0.00662 [0.00269, 0.01055]
age, sex, UKB array type, Genotype PCs
PPM007111 PGS001404
(GBE_INI4124)
PSS007322|
East Asian Ancestry|
782 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (R) : 0.09993 [0.07297, 0.12689]
Incremental R2 (full-covars): 0.0765
PGS R2 (no covariates): 0.0766 [0.05238, 0.10082]
age, sex, UKB array type, Genotype PCs
PPM007112 PGS001404
(GBE_INI4124)
PSS007323|
European Ancestry|
10,627 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (R) : 0.17605 [0.16746, 0.18463]
Incremental R2 (full-covars): 0.11134
PGS R2 (no covariates): 0.11225 [0.10487, 0.11964]
age, sex, UKB array type, Genotype PCs
PPM007113 PGS001404
(GBE_INI4124)
PSS007324|
South Asian Ancestry|
5,032 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (R) : 0.08461 [0.07282, 0.0964]
Incremental R2 (full-covars): 0.05881
PGS R2 (no covariates): 0.05872 [0.04862, 0.06882]
age, sex, UKB array type, Genotype PCs
PPM007114 PGS001404
(GBE_INI4124)
PSS007325|
European Ancestry|
25,715 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Heel bone mineral density (BMD) (R) : 0.196 [0.19063, 0.20138]
Incremental R2 (full-covars): 0.12507
PGS R2 (no covariates): 0.12352 [0.11887, 0.12817]
age, sex, UKB array type, Genotype PCs
PPM010515 PGS001955
(portability-PLR_log_heel_BMD)
PSS009446|
European Ancestry|
11,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.4537 [0.4391, 0.4682] sex, age, birth date, deprivation index, 16 PCs
PPM010516 PGS001955
(portability-PLR_log_heel_BMD)
PSS009220|
European Ancestry|
2,146 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.4397 [0.4048, 0.4734] sex, age, birth date, deprivation index, 16 PCs
PPM010519 PGS001955
(portability-PLR_log_heel_BMD)
PSS008326|
South Asian Ancestry|
1,972 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.3477 [0.3081, 0.3861] sex, age, birth date, deprivation index, 16 PCs
PPM010520 PGS001955
(portability-PLR_log_heel_BMD)
PSS008103|
East Asian Ancestry|
820 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.3057 [0.2415, 0.3672] sex, age, birth date, deprivation index, 16 PCs
PPM010521 PGS001955
(portability-PLR_log_heel_BMD)
PSS007890|
African Ancestry|
790 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.1895 [0.1204, 0.2567] sex, age, birth date, deprivation index, 16 PCs
PPM010522 PGS001955
(portability-PLR_log_heel_BMD)
PSS008994|
African Ancestry|
1,406 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.1746 [0.1231, 0.2252] sex, age, birth date, deprivation index, 16 PCs
PPM010517 PGS001955
(portability-PLR_log_heel_BMD)
PSS008774|
European Ancestry|
3,461 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.3929 [0.3643, 0.4208] sex, age, birth date, deprivation index, 16 PCs
PPM010518 PGS001955
(portability-PLR_log_heel_BMD)
PSS008548|
Greater Middle Eastern Ancestry|
506 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.2944 [0.211, 0.3736] sex, age, birth date, deprivation index, 16 PCs
PPM012231 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS009446|
European Ancestry|
11,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.4429 [0.428, 0.4575] sex, age, birth date, deprivation index, 16 PCs
PPM012232 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS009220|
European Ancestry|
2,146 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.4242 [0.3886, 0.4584] sex, age, birth date, deprivation index, 16 PCs
PPM012233 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS008774|
European Ancestry|
3,461 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.384 [0.3551, 0.4121] sex, age, birth date, deprivation index, 16 PCs
PPM012234 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS008548|
Greater Middle Eastern Ancestry|
506 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.3123 [0.2297, 0.3904] sex, age, birth date, deprivation index, 16 PCs
PPM012235 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS008326|
South Asian Ancestry|
1,972 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.338 [0.2981, 0.3767] sex, age, birth date, deprivation index, 16 PCs
PPM012236 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS008103|
East Asian Ancestry|
820 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.285 [0.22, 0.3474] sex, age, birth date, deprivation index, 16 PCs
PPM012237 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS007890|
African Ancestry|
790 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.1699 [0.1005, 0.2377] sex, age, birth date, deprivation index, 16 PCs
PPM012238 PGS002173
(portability-ldpred2_log_heel_BMD)
PSS008994|
African Ancestry|
1,406 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Heel bone mineral density (BMD) Partial Correlation (partial-r): 0.1647 [0.113, 0.2154] sex, age, birth date, deprivation index, 16 PCs
PPM013080 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0299 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013129 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.087 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013178 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.2324 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013227 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1529 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013368 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013417 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0509 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013515 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0961 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013466 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1523 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013564 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013613 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0318 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013662 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1546 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013711 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0589 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013760 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013809 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.01 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013858 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1186 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013907 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0253 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013956 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0195 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014005 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.046 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014054 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1395 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014103 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0891 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014152 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0203 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014201 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0426 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014250 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1328 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014299 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0836 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014348 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0416 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014397 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0991 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014446 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.2504 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014495 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1707 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014544 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0298 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014593 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0805 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014642 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.228 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014691 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1583 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008774 3,461 individuals European Italy (South Europe) UKB
PSS007241 2,248 individuals African unspecified UKB
PSS007242 794 individuals East Asian UKB
PSS007243 12,374 individuals European non-white British ancestry UKB
PSS007244 2,310 individuals South Asian UKB
PSS007245 38,814 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007890 790 individuals African American or Afro-Caribbean Carribean UKB
PSS008994 1,406 individuals African unspecified Nigeria (West Africa) UKB
PSS008548 506 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009446 11,484 individuals European UK (+ Ireland) UKB
PSS000212 902 individuals,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000212 557 individuals,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000213
[
  • 95 cases
  • , 807 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000213
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000214
[
  • 395 cases
  • , 507 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000214
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000215
[
  • 166 cases
  • , 736 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000215
[
  • 53 cases
  • , 504 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000216
[
  • 103 cases
  • , 799 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000216
[
  • 9 cases
  • , 548 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS009706 7,588 individuals South Asian UKB
PSS007291 3,558 individuals African unspecified UKB
PSS007292 781 individuals East Asian UKB
PSS007293 10,626 individuals European non-white British ancestry UKB
PSS007294 5,037 individuals South Asian UKB
PSS007295 25,706 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007296 3,560 individuals African unspecified UKB
PSS007297 781 individuals East Asian UKB
PSS007298 10,636 individuals European non-white British ancestry UKB
PSS007299 5,043 individuals South Asian UKB
PSS007300 25,716 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009220 2,146 individuals European Poland (NE Europe) UKB
PSS008326 1,972 individuals South Asian India (South Asia) UKB
PSS009703 5,639 individuals African unspecified UKB
PSS009704 889 individuals East Asian UKB
PSS007321 3,586 individuals African unspecified UKB
PSS007322 782 individuals East Asian UKB
PSS007323 10,627 individuals European non-white British ancestry UKB
PSS007324 5,032 individuals South Asian UKB
PSS007325 25,715 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007326 3,592 individuals African unspecified UKB
PSS007327 782 individuals East Asian UKB
PSS007328 10,633 individuals European non-white British ancestry UKB
PSS007329 5,041 individuals South Asian UKB
PSS007330 25,728 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008103 820 individuals East Asian China (East Asia) UKB
PSS009705 42,030 individuals European Non-British European UKB
PSS007476 2,253 individuals African unspecified UKB
PSS007477 795 individuals East Asian UKB
PSS007478 12,376 individuals European non-white British ancestry UKB
PSS007479 2,312 individuals South Asian UKB
PSS007480 38,834 individuals European white British ancestry UKB Testing cohort (heldout set)