Trait: cardiac arrhythmia

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004269
Description Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Trait categories
Cardiovascular disease
Other disease
Synonyms 4 synonyms
  • arrhythmia
  • arrhythmias, cardiac
  • arrythmia
  • cardiac arrhythmias
Child trait(s) paroxysmal tachycardia

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "cardiac arrhythmia" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019185
(TPMI_427_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cardiac dysrhythmias cardiac arrhythmia 2,731
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019185/ScoringFiles/PGS019185.txt.gz
PGS019186
(TPMI_427_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cardiac dysrhythmias cardiac arrhythmia 939,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019186/ScoringFiles/PGS019186.txt.gz
PGS019187
(TPMI_427_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cardiac dysrhythmias cardiac arrhythmia 38,526
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019187/ScoringFiles/PGS019187.txt.gz
PGS019188
(TPMI_427_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cardiac dysrhythmias cardiac arrhythmia 983,828
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019188/ScoringFiles/PGS019188.txt.gz
PGS019189
(TPMI_427_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cardiac dysrhythmias cardiac arrhythmia 144,250
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019189/ScoringFiles/PGS019189.txt.gz
PGS019190
(TPMI_427.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 70
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019190/ScoringFiles/PGS019190.txt.gz
PGS019191
(TPMI_427.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 215,523
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019191/ScoringFiles/PGS019191.txt.gz
PGS019192
(TPMI_427.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 593,905
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019192/ScoringFiles/PGS019192.txt.gz
PGS019193
(TPMI_427.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019193/ScoringFiles/PGS019193.txt.gz
PGS019194
(TPMI_427.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 1,005,558
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019194/ScoringFiles/PGS019194.txt.gz
PGS019200
(TPMI_427.5_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Arrhythmia cardiac NOS cardiac arrhythmia 11
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019200/ScoringFiles/PGS019200.txt.gz
PGS019201
(TPMI_427.5_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Arrhythmia cardiac NOS cardiac arrhythmia 939,875
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019201/ScoringFiles/PGS019201.txt.gz
PGS019202
(TPMI_427.5_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Arrhythmia cardiac NOS cardiac arrhythmia 14,836
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019202/ScoringFiles/PGS019202.txt.gz
PGS019203
(TPMI_427.5_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Arrhythmia cardiac NOS cardiac arrhythmia 983,820
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019203/ScoringFiles/PGS019203.txt.gz
PGS019204
(TPMI_427.5_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Arrhythmia cardiac NOS cardiac arrhythmia 955,432
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019204/ScoringFiles/PGS019204.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037367 PGS019185
(TPMI_427_Lassosum2)
 PSS013113|
East Asian Ancestry|
19,465 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cardiac dysrhythmias — AUROC: 0.59771 R²: 0.03055 sex, age, array, PCs 1-10 —
PPM037368 PGS019186
(TPMI_427_LDpred2)
 PSS013112|
East Asian Ancestry|
19,465 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cardiac dysrhythmias — AUROC: 0.60028 R²: 0.03211 sex, age, array, PCs 1-10 —
PPM037369 PGS019187
(TPMI_427_MegaPRS)
 PSS013114|
East Asian Ancestry|
19,465 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cardiac dysrhythmias — AUROC: 0.59639 R²: 0.02961 sex, age, array, PCs 1-10 —
PPM037370 PGS019188
(TPMI_427_PRS-CS)
 PSS013115|
East Asian Ancestry|
19,465 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cardiac dysrhythmias — AUROC: 0.59933 R²: 0.03192 sex, age, array, PCs 1-10 —
PPM037371 PGS019189
(TPMI_427_SBayesR)
 PSS013116|
East Asian Ancestry|
19,465 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cardiac dysrhythmias — AUROC: 0.5964 R²: 0.02941 sex, age, array, PCs 1-10 —
PPM037372 PGS019190
(TPMI_427.1_Lassosum2)
 PSS013088|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60796 R²: 0.00608 sex, age, array, PCs 1-10 —
PPM037373 PGS019191
(TPMI_427.1_LDpred2)
 PSS013087|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60822 R²: 0.00609 sex, age, array, PCs 1-10 —
PPM037374 PGS019192
(TPMI_427.1_MegaPRS)
 PSS013089|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.6094 R²: 0.00622 sex, age, array, PCs 1-10 —
PPM037375 PGS019193
(TPMI_427.1_PRS-CS)
 PSS013090|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60689 R²: 0.00598 sex, age, array, PCs 1-10 —
PPM037376 PGS019194
(TPMI_427.1_SBayesR)
 PSS013091|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60875 R²: 0.00611 sex, age, array, PCs 1-10 —
PPM037382 PGS019200
(TPMI_427.5_Lassosum2)
 PSS013103|
East Asian Ancestry|
18,201 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Arrhythmia cardiac NOS — AUROC: 0.63874 R²: 0.03526 sex, age, array, PCs 1-10 —
PPM037383 PGS019201
(TPMI_427.5_LDpred2)
 PSS013102|
East Asian Ancestry|
18,201 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Arrhythmia cardiac NOS — AUROC: 0.63859 R²: 0.03539 sex, age, array, PCs 1-10 —
PPM037384 PGS019202
(TPMI_427.5_MegaPRS)
 PSS013104|
East Asian Ancestry|
18,201 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Arrhythmia cardiac NOS — AUROC: 0.64042 R²: 0.03586 sex, age, array, PCs 1-10 —
PPM037385 PGS019203
(TPMI_427.5_PRS-CS)
 PSS013105|
East Asian Ancestry|
18,201 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Arrhythmia cardiac NOS — AUROC: 0.6374 R²: 0.03475 sex, age, array, PCs 1-10 —
PPM037386 PGS019204
(TPMI_427.5_SBayesR)
 PSS013106|
East Asian Ancestry|
18,201 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Arrhythmia cardiac NOS — AUROC: 0.63709 R²: 0.03468 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013087 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013088 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013089 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013090 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013091 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013102 427.9,I49.9 —
[
  • 684 cases
  • , 17,517 controls
]
,
45.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013103 427.9,I49.9 —
[
  • 684 cases
  • , 17,517 controls
]
,
45.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013104 427.9,I49.9 —
[
  • 684 cases
  • , 17,517 controls
]
,
45.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013105 427.9,I49.9 —
[
  • 684 cases
  • , 17,517 controls
]
,
45.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013106 427.9,I49.9 —
[
  • 684 cases
  • , 17,517 controls
]
,
45.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013112 427, 785.0, 785.1, V12.53,I46, I47, I48, I49.0, I49.1, I49.2, I49.3, I49.4, I49.5, I49.8, I49.9, R00.0, R00.1, R00.2, Z86.74 —
[
  • 1,948 cases
  • , 17,517 controls
]
,
46.01 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013113 427, 785.0, 785.1, V12.53,I46, I47, I48, I49.0, I49.1, I49.2, I49.3, I49.4, I49.5, I49.8, I49.9, R00.0, R00.1, R00.2, Z86.74 —
[
  • 1,948 cases
  • , 17,517 controls
]
,
46.01 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013114 427, 785.0, 785.1, V12.53,I46, I47, I48, I49.0, I49.1, I49.2, I49.3, I49.4, I49.5, I49.8, I49.9, R00.0, R00.1, R00.2, Z86.74 —
[
  • 1,948 cases
  • , 17,517 controls
]
,
46.01 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013115 427, 785.0, 785.1, V12.53,I46, I47, I48, I49.0, I49.1, I49.2, I49.3, I49.4, I49.5, I49.8, I49.9, R00.0, R00.1, R00.2, Z86.74 —
[
  • 1,948 cases
  • , 17,517 controls
]
,
46.01 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013116 427, 785.0, 785.1, V12.53,I46, I47, I48, I49.0, I49.1, I49.2, I49.3, I49.4, I49.5, I49.8, I49.9, R00.0, R00.1, R00.2, Z86.74 —
[
  • 1,948 cases
  • , 17,517 controls
]
,
46.01 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —