Trait: waist circumference

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004342
Description The measurement around the body at the level of the ABDOMEN and just above the hip bone. The measurement is usually taken immediately after exhalation.
Trait category
Body measurement
Mapped terms 4 mapped terms
  • MeSH:D055105
  • MedDRA:10074998
  • NCIt:C100948
  • SNOMEDCT:276361009

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000827
(WaistCircumference_PGS_M)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Waist circumference (male) waist circumference,
male
113
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000827/ScoringFiles/PGS000827.txt.gz - Check Terms/Licenses
PGS000828
(WaistCircumference_PGS_F)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Waist circumference (female) waist circumference,
female
149
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000828/ScoringFiles/PGS000828.txt.gz - Check Terms/Licenses
PGS001227
(GBE_INI48)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Waist circumference waist circumference 25,538
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001227/ScoringFiles/PGS001227.txt.gz
PGS001983
(portability-PLR_log_waist_circ)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Waist circumference waist circumference 96,496
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001983/ScoringFiles/PGS001983.txt.gz
PGS002201
(portability-ldpred2_log_waist_circ)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Waist circumference waist circumference 984,035
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002201/ScoringFiles/PGS002201.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002234 PGS000827
(WaistCircumference_PGS_M)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Waist circumference (male) : 0.018 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002233 PGS000828
(WaistCircumference_PGS_F)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Waist circumference (female) : 0.032 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM008649 PGS001227
(GBE_INI48)
PSS007356|
African Ancestry|
6,418 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Waist circumference : 0.04902 [0.03878, 0.05925]
Incremental R2 (full-covars): 0.01275
PGS R2 (no covariates): 0.01765 [0.01131, 0.024]
age, sex, UKB array type, Genotype PCs
PPM008650 PGS001227
(GBE_INI48)
PSS007357|
East Asian Ancestry|
1,698 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Waist circumference : 0.31538 [0.27895, 0.35182]
Incremental R2 (full-covars): 0.00143
PGS R2 (no covariates): 0.02593 [0.01107, 0.0408]
age, sex, UKB array type, Genotype PCs
PPM008651 PGS001227
(GBE_INI48)
PSS007358|
European Ancestry|
24,833 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Waist circumference : 0.30589 [0.29635, 0.31542]
Incremental R2 (full-covars): 0.05708
PGS R2 (no covariates): 0.0673 [0.06129, 0.07331]
age, sex, UKB array type, Genotype PCs
PPM008652 PGS001227
(GBE_INI48)
PSS007359|
South Asian Ancestry|
7,756 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Waist circumference : 0.19567 [0.17992, 0.21142]
Incremental R2 (full-covars): 0.03363
PGS R2 (no covariates): 0.03558 [0.02753, 0.04364]
age, sex, UKB array type, Genotype PCs
PPM008653 PGS001227
(GBE_INI48)
PSS007360|
European Ancestry|
67,330 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Waist circumference : 0.29142 [0.28565, 0.2972]
Incremental R2 (full-covars): 0.06556
PGS R2 (no covariates): 0.0665 [0.06287, 0.07013]
age, sex, UKB array type, Genotype PCs
PPM010739 PGS001983
(portability-PLR_log_waist_circ)
PSS009471|
European Ancestry|
19,966 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.3233 [0.3108, 0.3356] sex, age, birth date, deprivation index, 16 PCs
PPM010740 PGS001983
(portability-PLR_log_waist_circ)
PSS009245|
European Ancestry|
4,125 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.3113 [0.2834, 0.3387] sex, age, birth date, deprivation index, 16 PCs
PPM010741 PGS001983
(portability-PLR_log_waist_circ)
PSS008799|
European Ancestry|
6,637 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.303 [0.281, 0.3247] sex, age, birth date, deprivation index, 16 PCs
PPM010742 PGS001983
(portability-PLR_log_waist_circ)
PSS008573|
Greater Middle Eastern Ancestry|
1,181 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.248 [0.1932, 0.3012] sex, age, birth date, deprivation index, 16 PCs
PPM010743 PGS001983
(portability-PLR_log_waist_circ)
PSS008351|
South Asian Ancestry|
6,267 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.255 [0.2317, 0.2781] sex, age, birth date, deprivation index, 16 PCs
PPM010744 PGS001983
(portability-PLR_log_waist_circ)
PSS008128|
East Asian Ancestry|
1,802 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.2068 [0.1619, 0.2508] sex, age, birth date, deprivation index, 16 PCs
PPM010745 PGS001983
(portability-PLR_log_waist_circ)
PSS007915|
African Ancestry|
2,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.1624 [0.1235, 0.2008] sex, age, birth date, deprivation index, 16 PCs
PPM010746 PGS001983
(portability-PLR_log_waist_circ)
PSS009019|
African Ancestry|
3,868 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.1264 [0.0952, 0.1574] sex, age, birth date, deprivation index, 16 PCs
PPM012455 PGS002201
(portability-ldpred2_log_waist_circ)
PSS009471|
European Ancestry|
19,966 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.3243 [0.3118, 0.3367] sex, age, birth date, deprivation index, 16 PCs
PPM012456 PGS002201
(portability-ldpred2_log_waist_circ)
PSS009245|
European Ancestry|
4,125 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.3197 [0.292, 0.3469] sex, age, birth date, deprivation index, 16 PCs
PPM012457 PGS002201
(portability-ldpred2_log_waist_circ)
PSS008799|
European Ancestry|
6,637 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.3066 [0.2846, 0.3283] sex, age, birth date, deprivation index, 16 PCs
PPM012458 PGS002201
(portability-ldpred2_log_waist_circ)
PSS008573|
Greater Middle Eastern Ancestry|
1,181 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.2581 [0.2036, 0.311] sex, age, birth date, deprivation index, 16 PCs
PPM012460 PGS002201
(portability-ldpred2_log_waist_circ)
PSS008128|
East Asian Ancestry|
1,802 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.2159 [0.1712, 0.2597] sex, age, birth date, deprivation index, 16 PCs
PPM012461 PGS002201
(portability-ldpred2_log_waist_circ)
PSS007915|
African Ancestry|
2,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.1768 [0.138, 0.215] sex, age, birth date, deprivation index, 16 PCs
PPM012462 PGS002201
(portability-ldpred2_log_waist_circ)
PSS009019|
African Ancestry|
3,868 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.1284 [0.0972, 0.1593] sex, age, birth date, deprivation index, 16 PCs
PPM012459 PGS002201
(portability-ldpred2_log_waist_circ)
PSS008351|
South Asian Ancestry|
6,267 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Waist circumference Partial Correlation (partial-r): 0.2563 [0.2329, 0.2793] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007356 6,418 individuals African unspecified UKB
PSS007357 1,698 individuals East Asian UKB
PSS007358 24,833 individuals European non-white British ancestry UKB
PSS007359 7,756 individuals South Asian UKB
PSS007360 67,330 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007915 2,457 individuals African American or Afro-Caribbean Carribean UKB
PSS008573 1,181 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008128 1,802 individuals East Asian China (East Asia) UKB
PSS008351 6,267 individuals South Asian India (South Asia) UKB
PSS009019 3,868 individuals African unspecified Nigeria (West Africa) UKB
PSS009245 4,125 individuals European Poland (NE Europe) UKB
PSS009471 19,966 individuals European UK (+ Ireland) UKB
PSS008799 6,637 individuals European Italy (South Europe) UKB
PSS001083 Of the 2,531 participants, 1,809 had longitudinal observations for total cholesterol (mg/dL), high density lipoprotein cholesterol (mg/dL) and trigycerides (mg/dL), 1,801 had longitudinal observations for low density lipoprotein cholesterol (mg/dL), 1,325 had longitudinal observations for waist circumference (inches), 2,355 had longitudinal observations for body mass index (kg/m^2) and 1,572 had longitudinal observations for homocysteine (μmol/L). 2,531 individuals,
40.0 % Male samples
Mean = 48.0 years
Sd = 12.0 years
European, Asian unspecified, Hispanic or Latin American, African unspecified, NR European = 1,999, Asian unspecified = 228, Hispanic or Latin American = 101, African unspecified = 51, Not reported = 152 NR Participants were obtained from the Scientific Wellness Program.