Trait: serum albumin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004535
Description An albumin measurement is a quantification of albumin in blood. Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Low levels of albumin in the blood may indicate liver disease.
Trait category
Other measurement
Synonym blood albumin
Mapped term NCIt:C61015

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000669
(snpnet.Albumin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Albumin [g/L] serum albumin measurement 11,912
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000669/ScoringFiles/PGS000669.txt.gz - Check Terms/Licenses
PGS001886
(portability-PLR_albumin)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Albumin serum albumin measurement 60,423
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001886/ScoringFiles/PGS001886.txt.gz
PGS002099
(portability-ldpred2_albumin)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Albumin serum albumin measurement 816,264
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002099/ScoringFiles/PGS002099.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001397 PGS000669
(snpnet.Albumin)
PSS000627|
African Ancestry|
5,573 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.10081
Spearman's ρ: 0.121
Age, sex, PCs(1-40)
PPM001432 PGS000669
(snpnet.Albumin)
PSS000628|
East Asian Ancestry|
984 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.08916
Spearman's ρ: 0.198
Age, sex, PCs(1-40)
PPM001467 PGS000669
(snpnet.Albumin)
PSS000629|
European Ancestry|
21,516 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.13257
Spearman's ρ: 0.25
Age, sex, PCs(1-40)
PPM001502 PGS000669
(snpnet.Albumin)
PSS000630|
South Asian Ancestry|
6,687 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.15158
Spearman's ρ: 0.216
Age, sex, PCs(1-40)
PPM001537 PGS000669
(snpnet.Albumin)
PSS000631|
European Ancestry|
58,196 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.13054
Spearman's ρ: 0.262
Age, sex, PCs(1-40)
PPM007270 PGS000669
(snpnet.Albumin)
PSS007066|
African Ancestry|
5,658 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Albumin : 0.07255 [0.06041, 0.08469]
Incremental R2 (full-covars): 0.00087
PGS R2 (no covariates): 0.01339 [0.00784, 0.01894]
age, sex, UKB array type, Genotype PCs
PPM007271 PGS000669
(snpnet.Albumin)
PSS007067|
East Asian Ancestry|
1,472 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Albumin : 0.02049 [0.0072, 0.03378]
Incremental R2 (full-covars): 0.00193
PGS R2 (no covariates): 0.05108 [0.03075, 0.0714]
age, sex, UKB array type, Genotype PCs
PPM007272 PGS000669
(snpnet.Albumin)
PSS007068|
European Ancestry|
21,759 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Albumin : 0.04362 [0.03866, 0.04859]
Incremental R2 (full-covars): 0.00252
PGS R2 (no covariates): 0.0618 [0.05601, 0.06759]
age, sex, UKB array type, Genotype PCs
PPM007273 PGS000669
(snpnet.Albumin)
PSS007069|
South Asian Ancestry|
6,786 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Albumin : 0.0904 [0.07829, 0.10251]
Incremental R2 (full-covars): 0.00198
PGS R2 (no covariates): 0.04739 [0.03821, 0.05657]
age, sex, UKB array type, Genotype PCs
PPM007274 PGS000669
(snpnet.Albumin)
PSS007070|
European Ancestry|
59,097 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Albumin : 0.03793 [0.0351, 0.04076]
Incremental R2 (full-covars): 0.00267
PGS R2 (no covariates): 0.06779 [0.06413, 0.07145]
age, sex, UKB array type, Genotype PCs
PPM009972 PGS001886
(portability-PLR_albumin)
PSS009382|
European Ancestry|
17,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2949 [0.2813, 0.3084] sex, age, birth date, deprivation index, 16 PCs
PPM009973 PGS001886
(portability-PLR_albumin)
PSS009156|
European Ancestry|
3,593 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2758 [0.2452, 0.3058] sex, age, birth date, deprivation index, 16 PCs
PPM009974 PGS001886
(portability-PLR_albumin)
PSS008710|
European Ancestry|
5,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2722 [0.2482, 0.2959] sex, age, birth date, deprivation index, 16 PCs
PPM009975 PGS001886
(portability-PLR_albumin)
PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2704 [0.2124, 0.3264] sex, age, birth date, deprivation index, 16 PCs
PPM009976 PGS001886
(portability-PLR_albumin)
PSS008262|
South Asian Ancestry|
5,478 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2714 [0.2467, 0.2958] sex, age, birth date, deprivation index, 16 PCs
PPM009977 PGS001886
(portability-PLR_albumin)
PSS008040|
East Asian Ancestry|
1,560 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.226 [0.178, 0.2729] sex, age, birth date, deprivation index, 16 PCs
PPM009978 PGS001886
(portability-PLR_albumin)
PSS007826|
African Ancestry|
2,159 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1475 [0.1058, 0.1887] sex, age, birth date, deprivation index, 16 PCs
PPM009979 PGS001886
(portability-PLR_albumin)
PSS008930|
African Ancestry|
3,401 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1407 [0.1075, 0.1736] sex, age, birth date, deprivation index, 16 PCs
PPM011648 PGS002099
(portability-ldpred2_albumin)
PSS009382|
European Ancestry|
17,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.289 [0.2754, 0.3026] sex, age, birth date, deprivation index, 16 PCs
PPM011649 PGS002099
(portability-ldpred2_albumin)
PSS009156|
European Ancestry|
3,593 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2771 [0.2465, 0.3071] sex, age, birth date, deprivation index, 16 PCs
PPM011650 PGS002099
(portability-ldpred2_albumin)
PSS008710|
European Ancestry|
5,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2717 [0.2476, 0.2954] sex, age, birth date, deprivation index, 16 PCs
PPM011651 PGS002099
(portability-ldpred2_albumin)
PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2567 [0.1983, 0.3132] sex, age, birth date, deprivation index, 16 PCs
PPM011652 PGS002099
(portability-ldpred2_albumin)
PSS008262|
South Asian Ancestry|
5,478 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.265 [0.2402, 0.2895] sex, age, birth date, deprivation index, 16 PCs
PPM011653 PGS002099
(portability-ldpred2_albumin)
PSS008040|
East Asian Ancestry|
1,560 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.2305 [0.1827, 0.2773] sex, age, birth date, deprivation index, 16 PCs
PPM011654 PGS002099
(portability-ldpred2_albumin)
PSS007826|
African Ancestry|
2,159 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1481 [0.1063, 0.1893] sex, age, birth date, deprivation index, 16 PCs
PPM011655 PGS002099
(portability-ldpred2_albumin)
PSS008930|
African Ancestry|
3,401 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Albumin Partial Correlation (partial-r): 0.1569 [0.1238, 0.1896] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007068 21,759 individuals European non-white British ancestry UKB
PSS007069 6,786 individuals South Asian UKB
PSS007070 59,097 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009382 17,457 individuals European UK (+ Ireland) UKB
PSS009156 3,593 individuals European Poland (NE Europe) UKB
PSS008710 5,803 individuals European Italy (South Europe) UKB
PSS008484 1,036 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008262 5,478 individuals South Asian India (South Asia) UKB
PSS008040 1,560 individuals East Asian China (East Asia) UKB
PSS000627 5,573 individuals African unspecified UKB
PSS000628 984 individuals East Asian UKB
PSS000629 21,516 individuals European Non-British White UKB
PSS000630 6,687 individuals South Asian UKB
PSS000631 58,196 individuals European
(British)
UKB
PSS007826 2,159 individuals African American or Afro-Caribbean Carribean UKB
PSS008930 3,401 individuals African unspecified Nigeria (West Africa) UKB
PSS007066 5,658 individuals African unspecified UKB
PSS007067 1,472 individuals East Asian UKB