Trait: serum albumin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004535
Description
  • An albumin measurement is a quantification of albumin in blood. Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Low levels of albumin in the blood may indicate liver disease.
Trait category
Other measurement
Synonyms blood albumin
Mapped term(s) NCIt:C61015

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000669
(snpnet.Albumin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Albumin [g/L] serum albumin measurement 11,912
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000669/ScoringFiles/PGS000669.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001537 PGS000669
(snpnet.Albumin)
PSS000631|
European Ancestry|
58,196 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.13054
Spearman's ρ: 0.262
Age, sex, PCs(1-40)
PPM001502 PGS000669
(snpnet.Albumin)
PSS000630|
South Asian Ancestry|
6,687 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.15158
Spearman's ρ: 0.216
Age, sex, PCs(1-40)
PPM001467 PGS000669
(snpnet.Albumin)
PSS000629|
European Ancestry|
21,516 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.13257
Spearman's ρ: 0.25
Age, sex, PCs(1-40)
PPM001432 PGS000669
(snpnet.Albumin)
PSS000628|
East Asian Ancestry|
984 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.08916
Spearman's ρ: 0.198
Age, sex, PCs(1-40)
PPM001397 PGS000669
(snpnet.Albumin)
PSS000627|
African Ancestry|
5,573 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Albumin [g/L] : 0.10081
Spearman's ρ: 0.121
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000627 5,573 individuals African unspecified UKB
PSS000628 984 individuals East Asian UKB
PSS000629 21,516 individuals European Non-British White UKB
PSS000630 6,687 individuals South Asian UKB
PSS000631 58,196 individuals European
(British)
UKB