Trait: red blood cell distribution width

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005192
Description measure of the variation of red blood cell (RBC) volume
Trait category
Hematological measurement
Synonym RDW

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000188
(rdw)
PGP000078 |
Vuckovic D et al. Cell (2020)
Red cell distribution width red blood cell distribution width 546
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000188/ScoringFiles/PGS000188.txt.gz
PGS001152
(GBE_INI30070)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Red blood cell distribution width red blood cell distribution width 10,179
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001152/ScoringFiles/PGS001152.txt.gz
PGS001908
(portability-PLR_erythrocyte_width)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Red blood cell (erythrocyte) distribution width red blood cell distribution width 32,431
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001908/ScoringFiles/PGS001908.txt.gz
PGS002122
(portability-ldpred2_erythrocyte_width)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Red blood cell (erythrocyte) distribution width red blood cell distribution width 543,714
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002122/ScoringFiles/PGS002122.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000559 PGS000188
(rdw)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Red cell distribution width : 0.07409 sex, age, 10 genetic PCs
PPM000542 PGS000188
(rdw)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Red cell distribution width : 0.09519 sex, age, 10 genetic PCs
PPM008482 PGS001152
(GBE_INI30070)
PSS006941|
African Ancestry|
6,139 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Red blood cell distribution width : 0.02633 [0.01865, 0.03401]
Incremental R2 (full-covars): 0.00466
PGS R2 (no covariates): 0.00617 [0.00238, 0.00997]
age, sex, UKB array type, Genotype PCs
PPM008483 PGS001152
(GBE_INI30070)
PSS006942|
East Asian Ancestry|
1,655 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Red blood cell distribution width : 0.06947 [0.04623, 0.09271]
Incremental R2 (full-covars): 0.04028
PGS R2 (no covariates): 0.04714 [0.02754, 0.06675]
age, sex, UKB array type, Genotype PCs
PPM008484 PGS001152
(GBE_INI30070)
PSS006943|
European Ancestry|
24,175 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Red blood cell distribution width : 0.08241 [0.07587, 0.08895]
Incremental R2 (full-covars): 0.07409
PGS R2 (no covariates): 0.0754 [0.06909, 0.0817]
age, sex, UKB array type, Genotype PCs
PPM008485 PGS001152
(GBE_INI30070)
PSS006944|
South Asian Ancestry|
7,520 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Red blood cell distribution width : 0.06357 [0.05312, 0.07403]
Incremental R2 (full-covars): 0.04077
PGS R2 (no covariates): 0.04137 [0.03274, 0.05]
age, sex, UKB array type, Genotype PCs
PPM008486 PGS001152
(GBE_INI30070)
PSS006945|
European Ancestry|
65,638 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Red blood cell distribution width : 0.0852 [0.08117, 0.08923]
Incremental R2 (full-covars): 0.07926
PGS R2 (no covariates): 0.07945 [0.07553, 0.08337]
age, sex, UKB array type, Genotype PCs
PPM010147 PGS001908
(portability-PLR_erythrocyte_width)
PSS009400|
European Ancestry|
19,392 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3342 [0.3217, 0.3467] sex, age, birth date, deprivation index, 16 PCs
PPM010148 PGS001908
(portability-PLR_erythrocyte_width)
PSS009174|
European Ancestry|
3,996 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3297 [0.3017, 0.3571] sex, age, birth date, deprivation index, 16 PCs
PPM010149 PGS001908
(portability-PLR_erythrocyte_width)
PSS008728|
European Ancestry|
6,422 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2987 [0.2762, 0.3208] sex, age, birth date, deprivation index, 16 PCs
PPM010150 PGS001908
(portability-PLR_erythrocyte_width)
PSS008502|
Greater Middle Eastern Ancestry|
1,144 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2615 [0.2062, 0.3152] sex, age, birth date, deprivation index, 16 PCs
PPM010151 PGS001908
(portability-PLR_erythrocyte_width)
PSS008280|
South Asian Ancestry|
6,035 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2435 [0.2196, 0.2671] sex, age, birth date, deprivation index, 16 PCs
PPM010152 PGS001908
(portability-PLR_erythrocyte_width)
PSS008057|
East Asian Ancestry|
1,757 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2371 [0.1922, 0.281] sex, age, birth date, deprivation index, 16 PCs
PPM010154 PGS001908
(portability-PLR_erythrocyte_width)
PSS008948|
African Ancestry|
3,680 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.1241 [0.092, 0.1558] sex, age, birth date, deprivation index, 16 PCs
PPM010153 PGS001908
(portability-PLR_erythrocyte_width)
PSS007844|
African Ancestry|
2,328 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.1157 [0.0753, 0.1558] sex, age, birth date, deprivation index, 16 PCs
PPM011832 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS009174|
European Ancestry|
3,996 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3227 [0.2946, 0.3503] sex, age, birth date, deprivation index, 16 PCs
PPM011831 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS009400|
European Ancestry|
19,392 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.3341 [0.3215, 0.3465] sex, age, birth date, deprivation index, 16 PCs
PPM011833 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS008728|
European Ancestry|
6,422 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2938 [0.2713, 0.3161] sex, age, birth date, deprivation index, 16 PCs
PPM011834 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS008502|
Greater Middle Eastern Ancestry|
1,144 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2528 [0.1972, 0.3067] sex, age, birth date, deprivation index, 16 PCs
PPM011835 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS008280|
South Asian Ancestry|
6,035 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2424 [0.2185, 0.266] sex, age, birth date, deprivation index, 16 PCs
PPM011836 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS008057|
East Asian Ancestry|
1,757 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.2289 [0.1838, 0.273] sex, age, birth date, deprivation index, 16 PCs
PPM011837 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS007844|
African Ancestry|
2,328 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.0986 [0.058, 0.1388] sex, age, birth date, deprivation index, 16 PCs
PPM011838 PGS002122
(portability-ldpred2_erythrocyte_width)
PSS008948|
African Ancestry|
3,680 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Red blood cell (erythrocyte) distribution width Partial Correlation (partial-r): 0.1434 [0.1115, 0.175] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007844 2,328 individuals African American or Afro-Caribbean Carribean UKB
PSS006941 6,139 individuals African unspecified UKB
PSS006942 1,655 individuals East Asian UKB
PSS006943 24,175 individuals European non-white British ancestry UKB
PSS006944 7,520 individuals South Asian UKB
PSS006945 65,638 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS008948 3,680 individuals African unspecified Nigeria (West Africa) UKB
PSS009174 3,996 individuals European Poland (NE Europe) UKB
PSS008502 1,144 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009400 19,392 individuals European UK (+ Ireland) UKB
PSS008728 6,422 individuals European Italy (South Europe) UKB
PSS008280 6,035 individuals South Asian India (South Asia) UKB
PSS008057 1,757 individuals East Asian China (East Asia) UKB