Trait: cerebrospinal fluid volume measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008080
Description quantification of the volume of cerebrospinal fluid in the brain, usually through an MRI scan
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001070
(GBE_INI25003)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Volume of ventricular cerebrospinal fluid (normalised for head size) cerebrospinal fluid volume measurement 880
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001070/ScoringFiles/PGS001070.txt.gz
PGS001639
(GBE_INI25004)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Volume of ventricular cerebrospinal fluid neuroimaging measurement,
cerebrospinal fluid volume measurement
772
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001639/ScoringFiles/PGS001639.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005369 PGS001639
(GBE_INI25004)
PSS005205|
European Ancestry|
5,445 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid : 0.28661 [0.28085, 0.29238]
Incremental R2 (full-covars): 0.01665
PGS R2 (no covariates): 0.01482 [0.01301, 0.01663]
age, sex, UKB array type, Genotype PCs
PPM005368 PGS001639
(GBE_INI25004)
PSS005204|
South Asian Ancestry|
329 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid : 0.36613 [0.34915, 0.38311]
Incremental R2 (full-covars): 0.00516
PGS R2 (no covariates): 0.00707 [0.00337, 0.01077]
age, sex, UKB array type, Genotype PCs
PPM005367 PGS001639
(GBE_INI25004)
PSS005203|
European Ancestry|
1,739 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid : 0.28228 [0.27281, 0.29175]
Incremental R2 (full-covars): 0.01775
PGS R2 (no covariates): 0.01813 [0.01485, 0.02141]
age, sex, UKB array type, Genotype PCs
PPM005366 PGS001639
(GBE_INI25004)
PSS005202|
East Asian Ancestry|
113 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid : 0.349 [0.31255, 0.38544]
Incremental R2 (full-covars): 0.01036
PGS R2 (no covariates): 0.00796 [-0.00043, 0.01635]
age, sex, UKB array type, Genotype PCs
PPM005365 PGS001639
(GBE_INI25004)
PSS005201|
African Ancestry|
200 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid : 0.32375 [0.30505, 0.34246]
Incremental R2 (full-covars): 0.01105
PGS R2 (no covariates): 0.00559 [0.00198, 0.00921]
age, sex, UKB array type, Genotype PCs
PPM008112 PGS001070
(GBE_INI25003)
PSS005200|
European Ancestry|
5,445 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) : 0.25764 [0.25195, 0.26333]
Incremental R2 (full-covars): 0.01868
PGS R2 (no covariates): 0.01638 [0.01448, 0.01828]
age, sex, UKB array type, Genotype PCs
PPM008111 PGS001070
(GBE_INI25003)
PSS005199|
South Asian Ancestry|
329 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) : 0.39225 [0.3754, 0.4091]
Incremental R2 (full-covars): 0.00541
PGS R2 (no covariates): 0.00534 [0.00212, 0.00856]
age, sex, UKB array type, Genotype PCs
PPM008110 PGS001070
(GBE_INI25003)
PSS005198|
European Ancestry|
1,739 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) Incremental R2 (full-covars): 0.01559
: 0.2568 [0.24745, 0.26615]
PGS R2 (no covariates): 0.0141 [0.01119, 0.01701]
age, sex, UKB array type, Genotype PCs
PPM008109 PGS001070
(GBE_INI25003)
PSS005197|
East Asian Ancestry|
113 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) : 0.3397 [0.30323, 0.37618]
Incremental R2 (full-covars): 0.00796
PGS R2 (no covariates): 0.01224 [0.00189, 0.0226]
age, sex, UKB array type, Genotype PCs
PPM008108 PGS001070
(GBE_INI25003)
PSS005196|
African Ancestry|
200 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) : 0.29254 [0.27395, 0.31114]
Incremental R2 (full-covars): 0.01574
PGS R2 (no covariates): 0.00903 [0.00446, 0.01361]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005196 200 individuals African unspecified UKB
PSS005197 113 individuals East Asian UKB
PSS005198 1,739 individuals European non-white British ancestry UKB
PSS005199 329 individuals South Asian UKB
PSS005200 5,445 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS005201 200 individuals African unspecified UKB
PSS005202 113 individuals East Asian UKB
PSS005203 1,739 individuals European non-white British ancestry UKB
PSS005204 329 individuals South Asian UKB
PSS005205 5,445 individuals European white British ancestry UKB Testing cohort (heldout set)