Trait: Dementia

Trait Information
Identifier HP_0000726
Description A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior. [HPO: probinson]
Trait category
Other trait
Synonyms 3 synonyms
  • Dementia
  • Dementia, progressive
  • Progressive dementia
Mapped terms 8 mapped terms
  • DOID:1307
  • ICD10:F03
  • ICD9:290
  • MSH:D003704
  • NCIt:C4786
  • SNOMEDCT:52448006
  • SNOMEDCT_US:52448006
  • UMLS:C0497327

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000945
(GBE_HC710)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Dementia in alzheimer's disease (time-to-event) Alzheimer's disease,
Dementia
26
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000945/ScoringFiles/PGS000945.txt.gz
PGS000946
(GBE_HC713)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Unspecified dementia (time-to-event) Dementia 9
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000946/ScoringFiles/PGS000946.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007558 PGS000946
(GBE_HC713)
PSS004626|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE unspecified dementia AUROC: 0.83545 [0.80839, 0.8625] : 0.11896
Incremental AUROC (full-covars): 0.02339
PGS R2 (no covariates): 0.02543
PGS AUROC (no covariates): 0.64149 [0.59989, 0.68308]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007557 PGS000946
(GBE_HC713)
PSS004625|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE unspecified dementia AUROC: 0.90804 [0.86257, 0.9535] : 0.20027
Incremental AUROC (full-covars): 0.0061
PGS R2 (no covariates): 0.0151
PGS AUROC (no covariates): 0.56115 [0.41165, 0.71066]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007556 PGS000946
(GBE_HC713)
PSS004624|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE unspecified dementia AUROC: 0.82275 [0.77979, 0.86571] : 0.12092
Incremental AUROC (full-covars): 0.00342
PGS R2 (no covariates): 0.00838
PGS AUROC (no covariates): 0.57672 [0.50856, 0.64487]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007555 PGS000946
(GBE_HC713)
PSS004622|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE unspecified dementia AUROC: 0.82014 [0.73087, 0.90941] : 0.13536
Incremental AUROC (full-covars): 0.02407
PGS R2 (no covariates): 0.01431
PGS AUROC (no covariates): 0.57071 [0.42666, 0.71476]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007554 PGS000945
(GBE_HC710)
PSS004617|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.8916 [0.86249, 0.9207] : 0.16679
Incremental AUROC (full-covars): 0.05458
PGS R2 (no covariates): 0.06543
PGS AUROC (no covariates): 0.75273 [0.69847, 0.80699]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007553 PGS000945
(GBE_HC710)
PSS004616|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.9584 [0.92052, 0.99629] : 0.25982
Incremental AUROC (full-covars): 0.0131
PGS R2 (no covariates): 0.0675
PGS AUROC (no covariates): 0.67849 [0.36185, 0.99513]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007552 PGS000945
(GBE_HC710)
PSS004615|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.8807 [0.81377, 0.94763] : 0.16889
Incremental AUROC (full-covars): 0.0235
PGS R2 (no covariates): 0.04331
PGS AUROC (no covariates): 0.66609 [0.55451, 0.77766]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007551 PGS000945
(GBE_HC710)
PSS004614|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.98515 [0.97381, 0.9965] : 0.33632
Incremental AUROC (full-covars): 0.00807
PGS R2 (no covariates): 0.02667
PGS AUROC (no covariates): 0.7414 [0.59579, 0.88702]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004614
[
  • 5 cases
  • , 6,492 controls
]
African unspecified UKB
PSS004615
[
  • 27 cases
  • , 24,878 controls
]
European non-white British ancestry UKB
PSS004616
[
  • 6 cases
  • , 7,825 controls
]
South Asian UKB
PSS004617
[
  • 80 cases
  • , 67,345 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004622
[
  • 24 cases
  • , 6,473 controls
]
African unspecified UKB
PSS004624
[
  • 80 cases
  • , 24,825 controls
]
European non-white British ancestry UKB
PSS004625
[
  • 21 cases
  • , 7,810 controls
]
South Asian UKB
PSS004626
[
  • 197 cases
  • , 67,228 controls
]
European white British ancestry UKB Testing cohort (heldout set)