Trait: Abnormal blood glucose concentration

Trait Information
Identifier HP_0011015
Description An abnormality of the concentration of glucose in the blood.
Trait category
Other trait
Synonym Abnormality of blood glucose concentration
Child trait(s) Hypoglycemia

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "Abnormal blood glucose concentration" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001820
(portability-PLR_251.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hypoglycemia Hypoglycemia 187
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001820/ScoringFiles/PGS001820.txt.gz
PGS002028
(portability-ldpred2_251.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hypoglycemia Hypoglycemia 170,554
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002028/ScoringFiles/PGS002028.txt.gz
PGS018729
(TPMI_250.4_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abnormal glucose Abnormal blood glucose concentration 32
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018729/ScoringFiles/PGS018729.txt.gz
PGS018730
(TPMI_250.4_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abnormal glucose Abnormal blood glucose concentration 939,853
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018730/ScoringFiles/PGS018730.txt.gz
PGS018731
(TPMI_250.4_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abnormal glucose Abnormal blood glucose concentration 27,487
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018731/ScoringFiles/PGS018731.txt.gz
PGS018732
(TPMI_250.4_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abnormal glucose Abnormal blood glucose concentration 983,796
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018732/ScoringFiles/PGS018732.txt.gz
PGS018733
(TPMI_250.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abnormal glucose Abnormal blood glucose concentration 968,581
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018733/ScoringFiles/PGS018733.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009467 PGS001820
(portability-PLR_251.1)
 PSS008843|
African Ancestry|
3,403 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0115 [-0.0452, 0.0222] sex, age, birth date, deprivation index, 16 PCs —
PPM009462 PGS001820
(portability-PLR_251.1)
 PSS008618|
European Ancestry|
6,237 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0107 [-0.0142, 0.0355] sex, age, birth date, deprivation index, 16 PCs —
PPM009463 PGS001820
(portability-PLR_251.1)
 PSS008394|
Greater Middle Eastern Ancestry|
1,092 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0024 [-0.0575, 0.0622] sex, age, birth date, deprivation index, 16 PCs —
PPM009464 PGS001820
(portability-PLR_251.1)
 PSS008172|
South Asian Ancestry|
5,103 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0157 [-0.0118, 0.0432] sex, age, birth date, deprivation index, 16 PCs —
PPM009465 PGS001820
(portability-PLR_251.1)
 PSS007959|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0258 [-0.0733, 0.0219] sex, age, birth date, deprivation index, 16 PCs —
PPM009466 PGS001820
(portability-PLR_251.1)
 PSS007740|
African Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0074 [-0.0499, 0.0351] sex, age, birth date, deprivation index, 16 PCs —
PPM009460 PGS001820
(portability-PLR_251.1)
 PSS009290|
European Ancestry|
18,689 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0286 [0.0143, 0.043] sex, age, birth date, deprivation index, 16 PCs —
PPM009461 PGS001820
(portability-PLR_251.1)
 PSS009064|
European Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0119 [-0.0196, 0.0433] sex, age, birth date, deprivation index, 16 PCs —
PPM011098 PGS002028
(portability-ldpred2_251.1)
 PSS009290|
European Ancestry|
18,689 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0307 [0.0163, 0.045] sex, age, birth date, deprivation index, 16 PCs —
PPM011099 PGS002028
(portability-ldpred2_251.1)
 PSS009064|
European Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0136 [-0.0178, 0.0451] sex, age, birth date, deprivation index, 16 PCs —
PPM011100 PGS002028
(portability-ldpred2_251.1)
 PSS008618|
European Ancestry|
6,237 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0147 [-0.0101, 0.0396] sex, age, birth date, deprivation index, 16 PCs —
PPM011101 PGS002028
(portability-ldpred2_251.1)
 PSS008394|
Greater Middle Eastern Ancestry|
1,092 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0189 [-0.041, 0.0787] sex, age, birth date, deprivation index, 16 PCs —
PPM011102 PGS002028
(portability-ldpred2_251.1)
 PSS008172|
South Asian Ancestry|
5,103 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0134 [-0.0141, 0.0408] sex, age, birth date, deprivation index, 16 PCs —
PPM011103 PGS002028
(portability-ldpred2_251.1)
 PSS007959|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0153 [-0.0629, 0.0323] sex, age, birth date, deprivation index, 16 PCs —
PPM011104 PGS002028
(portability-ldpred2_251.1)
 PSS007740|
African Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0021 [-0.0404, 0.0446] sex, age, birth date, deprivation index, 16 PCs —
PPM011105 PGS002028
(portability-ldpred2_251.1)
 PSS008843|
African Ancestry|
3,403 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0158 [-0.0495, 0.0179] sex, age, birth date, deprivation index, 16 PCs —
PPM036911 PGS018729
(TPMI_250.4_Lassosum2)
 PSS012661|
East Asian Ancestry|
14,824 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abnormal glucose — AUROC: 0.58443 R²: 0.01746 sex, age, array, PCs 1-10 —
PPM036912 PGS018730
(TPMI_250.4_LDpred2)
 PSS012660|
East Asian Ancestry|
14,824 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abnormal glucose — AUROC: 0.5879 R²: 0.01843 sex, age, array, PCs 1-10 —
PPM036913 PGS018731
(TPMI_250.4_MegaPRS)
 PSS012662|
East Asian Ancestry|
14,824 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abnormal glucose — AUROC: 0.57977 R²: 0.0145 sex, age, array, PCs 1-10 —
PPM036914 PGS018732
(TPMI_250.4_PRS-CS)
 PSS012663|
East Asian Ancestry|
14,824 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abnormal glucose — AUROC: 0.58946 R²: 0.01774 sex, age, array, PCs 1-10 —
PPM036915 PGS018733
(TPMI_250.4_SBayesR)
 PSS012664|
East Asian Ancestry|
14,824 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abnormal glucose — AUROC: 0.58256 R²: 0.01521 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009064 — — 3,905 individuals — European Poland (NE Europe) UKB —
PSS008394 — — 1,092 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008618 — — 6,237 individuals — European Italy (South Europe) UKB —
PSS008172 — — 5,103 individuals — South Asian India (South Asia) UKB —
PSS008843 — — 3,403 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009290 — — 18,689 individuals — European UK (+ Ireland) UKB —
PSS012661 790.2,R73.0, R73.9 —
[
  • 818 cases
  • , 14,006 controls
]
,
42.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007959 — — 1,714 individuals — East Asian China (East Asia) UKB —
PSS012660 790.2,R73.0, R73.9 —
[
  • 818 cases
  • , 14,006 controls
]
,
42.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007740 — — 2,147 individuals — African American or Afro-Caribbean Carribean UKB —
PSS012662 790.2,R73.0, R73.9 —
[
  • 818 cases
  • , 14,006 controls
]
,
42.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012663 790.2,R73.0, R73.9 —
[
  • 818 cases
  • , 14,006 controls
]
,
42.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012664 790.2,R73.0, R73.9 —
[
  • 818 cases
  • , 14,006 controls
]
,
42.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —