Trait: fibromyalgia

Trait Information
Identifier MONDO_0005546
Description A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [NCIT: C87497]
Trait categories
Neurological disorder
Other disease
Synonyms 2 synonyms
  • fibromyalgia
  • fibromyalgia syndrome

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012560
(fibromyalgia_multiancestry)
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Fibromyalgia fibromyalgia 1,118,760
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012560/ScoringFiles/PGS012560.txt.gz
PGS012561
(fibromyalgia_European)
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Fibromyalgia fibromyalgia 1,113,197
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012561/ScoringFiles/PGS012561.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030689 PGS012560
(fibromyalgia_multiancestry)
 PSS012250|
European Ancestry|
422,581 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.59 — — —
PPM030691 PGS012560
(fibromyalgia_multiancestry)
 PSS012251|
South Asian Ancestry|
8,942 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.55 — — —
PPM030690 PGS012560
(fibromyalgia_multiancestry)
 PSS012249|
African Ancestry|
6,645 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.55 — — —
PPM030692 PGS012561
(fibromyalgia_European)
 PSS012250|
European Ancestry|
422,581 individuals
 PGP000801 |
Kerrebijn I et al. Nat Med (2026)
 Reported Trait: incident fibromyalgia cases — AUROC: 0.59 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012251 ICD 10 - M79.7 —
[
  • 226 cases
  • , 8,716 controls
]
 — South Asian — UKB —
PSS012249 ICD 10 - M79.7 —
[
  • 161 cases
  • , 6,484 controls
]
 — African unspecified — UKB —
PSS012250 ICD 10 - M79.7 —
[
  • 6,833 cases
  • , 415,748 controls
]
 — European — UKB —