PGS Publication: PGP000624

Publication Information (EuropePMC)
Title Cognitive trajectories diverge by genetic risk in a preclinical longitudinal cohort.
PubMed ID 36723444(Europe PMC)
doi 10.1002/alz.12920
Publication Date Feb. 1, 2023
Journal Alzheimers Dement
Author(s) Vasiljevic E, Koscik RL, Jonaitis E, Betthauser T, Johnson SC, Engelman CD.
Released in PGS Catalog: May 8, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004898
(PRS_AD)
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Alzheimer's disease Alzheimer disease 44
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004898/ScoringFiles/PGS004898.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021281 PGS004898
(PRS_AD)
 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Immediate learning β: -0.07 [-0.12, -0.02] — — Sex, years of education, testing practice effects —
PPM021282 PGS004898
(PRS_AD)
 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Delayed recall β: -0.07 [-0.12, -0.02] — — Sex, years of education, testing practice effects —
PPM021283 PGS004898
(PRS_AD)
 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Executive function β: -0.06 [-0.11, -0.01] — — Sex, years of education, testing practice effects —
PPM021284 PGS004898
(PRS_AD)
 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Preclinical Alzheimer Cognitive Composite (PACC3) β: -0.08 [-0.13, -0.04] — — Sex, years of education, testing practice effects —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011676 — — 1,135 individuals,
30.0 % Male samples
 Mean = 59.0 years
Sd = 6.0 years		 European — WRAP —