| Publication Information (EuropePMC) | |
| Title | Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery. |
| PubMed ID | 32517536(Europe PMC) |
| doi | 10.1161/circgen.119.002817 |
| Publication Date | June 9, 2020 |
| Journal | Circ Genom Precis Med |
| Author(s) | Douville NJ, Surakka I, Leis A, Douville CB, Hornsby WE, Brummett CM, Kheterpal S, Willer CJ, Engoren M, Mathis MR. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000013 (GPS_CAD) |
PGP000006 | Khera AV et al. Nat Genet (2018) |
Coronary artery disease | coronary artery disease | 6,630,150 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM021296 | PGS000013 (GPS_CAD) |
PSS011679| Multi-ancestry (including European)| 90,053 individuals |
PGP000626 | Douville NJ et al. Circ Genom Precis Med (2020) |Ext. |
Reported Trait: Myocardial injury following non cardiac surgery | OR: 1.23 [1.11, 1.37] | AUROC: 0.72 (0.011) | — | Age, sex, race | — |
| PPM021297 | PGS000013 (GPS_CAD) |
PSS011679| Multi-ancestry (including European)| 90,053 individuals |
PGP000626 | Douville NJ et al. Circ Genom Precis Med (2020) |Ext. |
Reported Trait: Myocardial injury following non cardiac surgery | OR: 1.12 [1.02, 1.24] | AUROC: 0.793 (0.014) | — | High-risk surgery, history of ischemic heart disease, history of congestive heart failure, history of cerebrovascular disease, insulin therapy for diabetes mellitus, preoperative creatinine >2.0 mg/dL | — |
| PPM021298 | PGS000013 (GPS_CAD) |
PSS011679| Multi-ancestry (including European)| 90,053 individuals |
PGP000626 | Douville NJ et al. Circ Genom Precis Med (2020) |Ext. |
Reported Trait: Myocardial injury following non cardiac surgery | OR: 1.19 [1.07, 1.31] | AUROC: 0.912 (0.006) | — | Age, admission type (admit and inpatient versus outpatient reference), composite RCRI score, history of a cardiac arrhythmia, history of fluid or electrolyte disorder, history of hypertension | — |
| PPM021299 | PGS000013 (GPS_CAD) |
PSS011679| Multi-ancestry (including European)| 90,053 individuals |
PGP000626 | Douville NJ et al. Circ Genom Precis Med (2020) |Ext. |
Reported Trait: Myocardial injury following non cardiac surgery | OR: 1.17 [1.06, 1.3] | AUROC: 0.921 (0.006) | — | Age, admission type (admit and inpatient versus outpatient reference), composite RCRI score, history of a cardiac arrhythmia, history of fluid or electrolyte disorder, history of hypertension, case duration (hours), pRBC transfusion (units), crystalloid resuscitation (L), estimated blood loss (L), total epinephrine dose (100mcg), total ephedrine dose (50mcg), total norepinephrine dose (40mcg), total phenylephrine dose (1000mcg), total vasopressin dose (10 units), time with myocardial injury after non cardiac surgery < 50 mmHg (min). | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011679 | Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation. | — | [
|
— | European | — | MGI | — |
| PSS011679 | Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation. | — | [
|
— | African unspecified | — | MGI | — |
| PSS011679 | Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation. | — | [
|
— | Asian unspecified, Oceanian | — | MGI | — |
| PSS011679 | Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation. | — | [
|
— | Native American | — | MGI | — |
| PSS011679 | Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation. | — | [
|
— | Not reported | — | MGI | — |