PGS Publication: PGP000628

Publication Information (EuropePMC)
Title Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses.
PubMed ID 33444330(Europe PMC)
doi 10.1371/journal.pmed.1003498
Publication Date Jan. 14, 2021
Journal PLoS Med
Author(s) Sun L, Pennells L, Kaptoge S, Nelson CP, Ritchie SC, Abraham G, Arnold M, Bell S, Bolton T, Burgess S, Dudbridge F, Guo Q, Sofianopoulou E, Stevens D, Thompson JR, Butterworth AS, Wood A, Danesh J, Samani NJ, Inouye M, Di Angelantonio E.
Released in PGS Catalog: May 8, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000039
(metaGRS_ischaemicstroke)
 PGP000027 |
Abraham G et al. Nat Commun (2019)
 Ischemic stroke stroke,
Ischemic stroke		 3,225,583
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000039/ScoringFiles/PGS000039.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021306 PGS000018
(metaGRS_CAD)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident cardiovascular disease outcome HR: 1.31 [1.27, 1.34] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021307 PGS000018
(metaGRS_CAD)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.49 [1.44, 1.54] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021308 PGS000018
(metaGRS_CAD)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.57 [1.51, 1.62] — — Age at baseline, stratified by study centre, sex —
PPM021309 PGS000018
(metaGRS_CAD)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.09 [1.04, 1.13] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021310 PGS000018
(metaGRS_CAD)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Combination of incident coronary heart disease, stroke and cardiac revascularisation procedures HR: 1.39 [1.36, 1.42] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021311 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident cardiovascular disease outcome HR: 1.18 [1.15, 1.21] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021312 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.16, 1.24] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021313 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.19 [1.14, 1.24] — — Age at baseline, stratified by study centre, sex —
PPM021314 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.16 [1.11, 1.21] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021315 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Combination of incident coronary heart disease, stroke and cardiac revascularisation procedures HR: 1.19 [1.16, 1.22] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011681 The primary outcome was a first-onset cardiovascular disease event, defined as the composite of CHD (i.e., myocardial infarction or fatal CHD) or any stroke. Secondary outcomes included each of CHD and stroke separately, and a combination of CHD, stroke, and cardiac revascularisation procedures (i.e., percutaneous transluminal cor- onary angioplasty [PTCA] and coronary artery bypass grafting [CABG]). 3333 Cases are CHD events and 2347 are stroke events Median = 8.1 years
[
  • 5,680 cases
  • , 300,974 controls
]
,
43.01 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European — UKB —