Trait: Moderate albuminuria

Trait Information
Identifier HP_0012594
Description The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol). [HPO_CONTRIBUTOR: Eurenomics_fschaefer] [PMID: 30571025]
Trait category
Other trait
Synonyms 2 synonyms
  • High urine albumin levels
  • Microalbuminuria
Mapped terms 3 mapped terms
  • SNOMEDCT_US:312975006
  • UMLS:C0730345
  • UMLS:C1654921

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004896
(mAlb)
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Microalbuminuria Moderate albuminuria 29
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004896/ScoringFiles/PGS004896.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021277 PGS004896
(mAlb)
 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Microalbuminuria OR: 1.014 [1.001, 1.027] — R²: 0.015 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —
PPM021280 PGS004896
(mAlb)
 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Urinary albumin-to-creatinine ratio β: 0.005 (0.002) — R²: 0.093 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011675 — — 389,206 individuals,
46.1 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European — UKB —