Latest Release - Nov. 10, 2025

New Publications (4)

PGS Publication/Study ID (PGP)	PGS Developed	PGS Evaluated	First Author	Title	Journal Name	Publication Date	Digital object identifier (doi)	PubMed ID (PMID)
PGP000757	1	1	Enzan N	Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.	Nat Commun	03/11/2025	10.1038/s41467-025-64659-6	41184235
PGP000770	7	2	Hrytsenko Y	Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.	Commun Med (Lond)	25/09/2025	10.1038/s43856-025-01107-y	40999017
PGP000750	3	3	Sarnowski C	Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.	Commun Biol	24/09/2025	10.1038/s42003-025-08674-9	40993182
PGP000733	1	1	Rand SA	Genome-wide association study and polygenic risk prediction of hypothyroidism.	Nat Genet	14/11/2025	10.1038/s41588-025-02410-z	41238958

New Polygenic Scores (12)

Filter PGS by Participant Ancestry

Individuals included in:

Any Stage [G, D, E] All Stages combined [G + D + E] Development [G, D]   - GWAS [G]   - Score development [D] PGS Evaluation [E]

G - Source of Variant Associations (GWAS)

D - Score Development/Training

E - PGS Evaluation

List of ancestries includes:

--AfricanEast AsianSouth AsianAdditional Asian AncestriesEuropeanGreater Middle EasternHispanic or Latin AmericanAdditional Diverse AncestriesNot Reported

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Additional Asian Ancestries

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Greater Middle Eastern

Hispanic or Latin American

Additional Diverse Ancestries

Not Reported

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS005218 (prsweights_hypothyroidism_excl23)	PGP000733 | Rand SA et al. Nat Genet (2025)	Hypothyroidism	hypothyroidism	1,110,091		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005218/ScoringFiles/PGS005218.txt.gz
PGS005276 (FI_PS_EUR)	PGP000750 | Sarnowski C et al. Commun Biol (2025)	Fasting insulin adjusted for BMI	BMI-adjusted fasting blood insulin measurement	1,116,555		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005276/ScoringFiles/PGS005276.txt.gz
PGS005277 (FI_PS_AFR)	PGP000750 | Sarnowski C et al. Commun Biol (2025)	Fasting insulin adjusted for BMI	BMI-adjusted fasting blood insulin measurement	1,233,791		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005277/ScoringFiles/PGS005277.txt.gz
PGS005278 (FI_PS_AMR)	PGP000750 | Sarnowski C et al. Commun Biol (2025)	Fasting insulin adjusted for BMI	BMI-adjusted fasting blood insulin measurement	1,182,208		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005278/ScoringFiles/PGS005278.txt.gz
PGS005285 (BBJ_HF_PRS_HG19)	PGP000757 | Enzan N et al. Nat Commun (2025)	Heart failure	heart failure	993,899	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005285/ScoringFiles/PGS005285.txt.gz
PGS005324 (T2D_PRS_weighted)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	1,279,733		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005324/ScoringFiles/PGS005324.txt.gz
PGS005325 (T2D_PRS_unweighted)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	1,279,733		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005325/ScoringFiles/PGS005325.txt.gz
PGS005326 (T2D_PRS_AFR)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	1,214,634	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005326/ScoringFiles/PGS005326.txt.gz
PGS005327 (T2D_PRS_AMR)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	972,776	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005327/ScoringFiles/PGS005327.txt.gz
PGS005328 (T2D_PRS_EAS)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	570,349	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005328/ScoringFiles/PGS005328.txt.gz
PGS005329 (T2D_PRS_EUR)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	1,112,468	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005329/ScoringFiles/PGS005329.txt.gz
PGS005330 (T2D_PRS_SAS)	PGP000770 | Hrytsenko Y et al. Commun Med (Lond) (2025)	Type 2 Diabetes Mellitus	type 2 diabetes mellitus	642,349	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005330/ScoringFiles/PGS005330.txt.gz