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(Variants and weights)

Polygenic Score (PGS) ID: PGS000011

Predicted Trait

Reported Trait: Coronary artery disease
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): coronary artery disease

Score Details

Name: GRS50

Original Genome Build: NR
Number of Variants: 50

PGS Development Method: Genome-wide significant SNPs
PGS Development Details/Relevant Parameters: Also includes the SNPs from GRS 27 (Mega et al.; PMID:25748612)

Citation: Tada H et al. Eur Heart J (2015) | PGS Catalog Publication ID: PGP000004

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
PubMed: 21966275.0 41,975 individuals
[ 11,202 cases, 30,773 controls]
PubMed: 21966275.0 8,653 individuals
[ 4,394 cases, 4,259 controls]
South Asian
PubMed: 23202125.0 194,427 individuals
[ 63,746 cases, 130,681 controls]
GWAS Catalog: GCST000338
PubMed: 19198612
2,520 individuals European
GWAS Catalog: GCST000999
PubMed: 21378988
14,790 individuals South Asian
(India, Pakistan)
GWAS Catalog: GCST000999
PubMed: 21378988
15,682 individuals European
GWAS Catalog: GCST000998
PubMed: 21378990
86,995 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000016 PSS000010 Tada H et al. (2015) Reported Trait: Incident coronary heart disease HR: 1.23 [1.18 - 1.28] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000029 PSS000018 Inouye M et al. (2018) Ext. Reported Trait: Incident coronary artery disease HR: 1.263 [1.247 - 1.28] sex, genetic PCs (1-10), genotyping array

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease. 23,595 individuals
[ 2,213 cases, 21,382 controls]
38.03 %% Male samples
MDC Prospective study
PSS000018 CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. 482,629 individuals
[ 22,242 cases, 460,387 controls]
45.60 %% Male samples
Other ~95% European ancestry samples, <5% non-European ancestry UKB