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(Variants and weights)

Polygenic Score (PGS) ID: PGS000020

Predicted Trait

Reported Trait: Type 2 diabetes
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): type II diabetes mellitus

Score Details

Name: dGRS1000

Original Genome Build: GRCh36
Number of Variants: 7,502

PGS Development Method: P+T
PGS Development Details/Relevant Parameters: P < 0.05, r2 < 0.05, betas are weighted by the probability that they are in the top 1000 signals

Citation: Läll K et al. Genet Med (2016) | PGS Catalog Publication ID: PGP000010

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST005047
PubMed: 22885922
69,033 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000040 PSS000025 Läll K et al. (2016) Reported Trait: Incident type 2 diabetes HR: 1.48 [1.32 - 1.66] C-index: 0.79 [0.771 - 0.812] BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. Cox age-as-time-scale

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000025 Incident cases of Type 2 Diabetes in 5.63 years follow-up 6,280 individuals
[ 302 cases, 5,978 controls]
55.00 %% Male samples