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(Variants and weights)

Polygenic Score (PGS) ID: PGS000024

Predicted Trait

Reported Trait: Type 1 diabetes
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): type I diabetes mellitus

Score Details

Name: GRS2

Original Genome Build: NR
Number of Variants: 67

PGS Development Method: Genome-wide significant associations and interaction modelling
PGS Development Details/Relevant Parameters: Significance threshold for interactions: p < 10^-4

Number of Variant Interaction Terms: 18

Citation: Sharp SA et al. Diabetes Care (2019) | PGS Catalog Publication ID: PGP000014

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST000392
PubMed: 19956093.0
16,086 individuals
[ 6,670 cases, 9,416 controls]

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000048 PSS000032 Sharp SA et al. (2019) Reported Trait: Type 1 diabetes AUROC: 0.921 Youden index: 0.698

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000032 Type 1 Diabetes Case Definition = Clinical diagnosis of diabetes at less than or equal to 20 years of age; On insulin within 1 year from the time of diagnosis; Still on insulin at the time of recruit- ment; Not using oral antihyperglycemic agents; Did not ever self-report as having type 2 diabetes (T2D) 374,000 individuals
[ 387 cases, 373,613 controls]
European UKB