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(Variants and weights)

Polygenic Score (PGS) ID: PGS000069

Predicted Trait

Reported Trait: Serous epithelial ovarian cancer
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): ovarian serous carcinoma

Score Details

Name: PRS_sEOC

Original Genome Build: GRCh37
Number of Variants: 15

PGS Development Method: Genomewide-significant SNPs
PGS Development Details/Relevant Parameters: P < 5x10-8 in GWAS for any type of EOC

Citation: Yang X et al. J Med Genet (2018) | PGS Catalog Publication ID: PGP000048

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST004478
PubMed: 28346442
54,990 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000189 PSS000108 Yang X et al. (2018) Reported Trait: serous epithelial ovarian cancer OR: 1.43 [1.29 - 1.58] C-index: 0.6 [0.57 - 0.63]

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee 2,178 individuals
[ 750 cases, 1,428 controls]
0.00 % Male samples
European UKCTOCS
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee 1,917 individuals
[ 489 cases, 1,428 controls]
0.00 % Male samples
European UKCTOCS