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(Variants and weights)

Polygenic Score (PGS) ID: PGS000070

Predicted Trait

Reported Trait: Lung cancer
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): lung adenocarcinoma

Score Details

Name: PRS_LC_C

Original Genome Build: GRCh37
Number of Variants: 19

PGS Development Method: Genomewide-significant SNPs, filtered to be specific to Chinese ancestry individuals
PGS Development Details/Relevant Parameters: Meta-anlaysis p-value ≤5·0 × 10−8; MAF < 0.01 (in Chinese populations); r2 >= 0.1; Chinese-specific association p-value < 0.00125

Citation: Dai J et al. Lancet Respir Med (2019) | PGS Catalog Publication ID: PGP000049

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST008834
PubMed: 31326317
26,655 individuals East Asian
GWAS Catalog: GCST008834
PubMed: 31326317
27,820 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000190 PSS000109 Dai J et al. (2019) Reported Trait: Incident lung cancer HR (High genetic risk: top 5% vs. bottom 5% of PRS): 2.37 [1.64 - 3.44]
HR (Intermediate genetic risk: 5-95% vs. bottom 5% of PRS): 1.6 [1.17 - 2.2]
age, sex, source of region, smoking status

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000109 Participants were followed-up for cancer events mainly through linkage with official death certificates, chronic disease registries, and the Chinese national health insurance system. 95,408 individuals
[ 1,316 cases, 94,092 controls]
42.93 % Male samples
East Asian
(Chinese)
CKB