PGS Publication: PGP000003

Publication Information (EuropePMC)
Title Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.
PubMed ID 25748612(Europe PMC)
doi 10.1016/S0140-6736(14)61730-X
Publication Date March 4, 2015
Journal Lancet
Author(s) Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, Nordio F, Hyde C, Cannon CP, Sacks F, Poulter N, Sever P, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS.
Released in PGS: Oct. 14, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000010 GRS27 PGP000003
Mega JL et al. Lancet (2015)
Coronary heart disease coronary heart disease 27 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000014 PGS000010 (GRS27) PSS000008 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.21[1.17, 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010 (GRS27) PSS000009 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.14[1.02, 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 149 cases
  • , 6,829 controls
]
,
79.7 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 320 cases
  • , 2,558 controls
]
,
86.1 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 229 cases
  • , 1,770 controls
]
,
77.5 % Male samples
European PROVEIT Secondary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals,
38.7 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 108 cases
  • , 8,641 controls
]
,
67.8 % Male samples
European JUPITER Primary prevention cohorts