Publication: Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.
Publication Date: Sept. 20, 2015
Journal: Eur Heart J
Authors: Tada H, Melander O, Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S, Shiffman D.
PGS Associated with PGP000004
PGS Developed By This Study
|Polygenic Score (PGS) ID||PGS Name||Publication ID||Reported Trait||Mapped Trait(s) (EFO)||Number of Variants||PGS Download Links|
|PGS000011||GRS50||Tada H et al. Eur Heart J (2015)||Coronary artery disease||coronary artery disease||50||FTP Link|
External PGS Evaluated By This Study
PGS Performance MetricsDisclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|PGS Performance Metric (PPM) ID||Evaluated Score||PGS Catalog Sample Set (PSS) ID||Performance Source||Trait||
PGS Effect Sizes
(per SD change)
|PGS Classification Metrics||Other Metrics||Covariates Included in PGS Model||PGS Performance: Other Relevant Information|
|PPM000016||PGS000011 (GRS50)||PSS000010||Tada H et al. (2015)||Reported Trait: Incident coronary heart disease||HR: 1.23 [1.18 - 1.28]||—||—||age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes||—|
|PPM000017||PGS000010 (GRS27)||PSS000010||Tada H et al. (2015) Ext.||Reported Trait: Incident coronary heart disease||HR: 1.2 [1.15 - 1.25]||—||—||age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes||—|
|PGS Catalog Sample Set (PSS) ID||Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases)||Sample Numbers||Sample Ancestry||Additional Ancestry Description||Cohort(s)||Additional Sample/Cohort Information|
|PSS000010||Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease.||23,595 individuals
[ 2,213 cases, 21,382 controls]
38.03 %% Male samples