PGS Publication: PGP000004

Publication Information (EuropePMC)
Title Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.
PubMed ID 26392438(Europe PMC)
doi 10.1093/eurheartj/ehv462
Publication Date Sept. 20, 2015
Journal Eur Heart J
Author(s) Tada H, Melander O, Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S, Shiffman D.
Released in PGS: Oct. 14, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000011 GRS50 PGP000004
Tada H et al. Eur Heart J (2015)
Coronary artery disease coronary artery disease 50 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000010 GRS27 PGP000003
Mega JL et al. Lancet (2015)
Coronary heart disease coronary heart disease 27 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000016 PGS000011 (GRS50) PSS000010 PGP000004
Tada H et al. (2015)
Reported Trait: Incident coronary heart disease HR: 1.23[1.18, 1.28] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000017 PGS000010 (GRS27) PSS000010 PGP000004
Tada H et al. (2015)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.2[1.15, 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease.
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
European
(Swedish)
MDC Prospective study