PGS Publication: PGP000010

Publication Information (EuropePMC)
Title Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores.
PubMed ID 27513194(Europe PMC)
doi 10.1038/gim.2016.103
Publication Date Aug. 11, 2016
Journal Genet Med
Author(s) Läll K, Mägi R, Morris A, Metspalu A, Fischer K.
Released in PGS: Oct. 14, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000020 dGRS1000 PGP000010
Läll K et al. Genet Med (2016)
Type 2 diabetes type II diabetes mellitus 7,502 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000020/ScoringFiles/PGS000020.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000040 PGS000020 (dGRS1000) PSS000025 PGP000010
Läll K et al. (2016)
Reported Trait: Incident type 2 diabetes HR: 1.48[1.32, 1.66] C-index: 0.79[0.771, 0.812] BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. Cox age-as-time-scale

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000025 Incident cases of Type 2 Diabetes in 5.63 years follow-up
[
  • 302 cases
  • , 5,978 controls
]
,
55.0 % Male samples
European
(Estonian)
EB