Publication: Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores.


PGS Catalog Publication (PGP) ID: PGP000010
PubMed ID: 27513194
doi: 10.1038/gim.2016.103

Publication Date: Aug. 11, 2016

Journal: Genet Med

Authors: Läll K, Mägi R, Morris A, Metspalu A, Fischer K.

PGS Associated with PGP000010

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000040 PGS000020 (dGRS1000) PSS000025 Läll K et al. (2016) Reported Trait: Incident type 2 diabetes HR: 1.48 [1.32 - 1.66] C-index: 0.79 [0.771 - 0.812] BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. Cox age-as-time-scale

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000025 Incident cases of Type 2 Diabetes in 5.63 years follow-up 6,280 individuals
[ 302 cases, 5,978 controls]
55.00 %% Male samples