Publication: Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.


PGS Catalog Publication (PGP) ID: PGP000013
PubMed ID: 30659077
doi: 10.2337/dc18-1727

Publication Date: Jan. 18, 2019

Journal: Diabetes Care

Authors: Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z, Oksenberg JR, Brant SR, Bridges SL, Edberg JC, Kimberly RP, Gregersen PK, Rewers MJ, Steck AK, Black MH, Dabelea D, Pihoker C, Atkinson MA, Wagenknecht LE, Divers J, Bell RA, SEARCH for Diabetes in Youth, Type 1 Diabetes Genetics Consortium, Erlich HA, Concannon P, Rich SS.

PGS Associated with PGP000013

PGS Developed By This Study

External PGS Evaluated By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000045 PGS000023 (AA_GRS) PSS000030 Onengut-Gumuscu S et al. (2019) Reported Trait: Type 1 diabetes AUROC: 0.87 NOTE: Evaluated using cross-validation on training samples (20% heldout, 1000 iterations)
PPM000046 PGS000021 (GRS1) PSS000030 Onengut-Gumuscu S et al. (2019) Ext. Reported Trait: Type 1 diabetes AUROC: 0.798
PPM000047 PGS000023 (AA_GRS) PSS000031 Onengut-Gumuscu S et al. (2019) Reported Trait: Type 1 diabetes AUROC: 0.779

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000030 3,949 individuals
[ 1,021 cases, 2,928 controls]
African unspecified BDC, CLEAR, GoKinD, NYCP, SEARCH, T1DGC, UAB
PSS000031 Cases are diagnosed with type 1 diabetes. 145 individuals
[ 61 cases, 54 controls]
African unspecified UOF