PGS Publication: PGP000017

Publication Information (EuropePMC)
Title Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
PubMed ID 31002795(Europe PMC)
doi 10.1016/j.cell.2019.03.028
Publication Date April 1, 2019
Journal Cell
Author(s) Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S.
Released in PGS: Oct. 14, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000027 GPS_BMI PGP000017
Khera AV et al. Cell (2019)
Body Mass Index body mass index 2,100,302

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000054 PGS000027 (GPS_BMI) PSS000037 PGP000017
Khera AV et al. (2019)
Reported Trait: Body mass index β: 1.41 : 0.08526 First 10 genetic PCs Beta is in units of kg/m^2

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000037 288,016 individuals,
45.0 % Male samples
European UKB