Publication: Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.


PGS Catalog Publication (PGP) ID: PGP000017
PubMed ID: 31002795
doi: 10.1016/j.cell.2019.03.028

Publication Date: April 1, 2019

Journal: Cell

Authors: Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S.

PGS Associated with PGP000017

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000054 PGS000027 (GPS_BMI) PSS000037 Khera AV et al. (2019) Reported Trait: Body mass index β: 1.41 : 0.085264 First 10 genetic PCs Beta is in units of kg/m^2

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000037 288,016 individuals
45.00 %% Male samples
European UKB