Publication: Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine.
Publication Date: Dec. 1, 2019
Journal: Endocr Rev
Authors: Udler MS, McCarthy MI, Florez JC, Mahajan A.
PGS Associated with PGP000024
External PGS Evaluated By This Study
PGS Performance MetricsDisclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|PGS Performance Metric (PPM) ID||Evaluated Score||PGS Catalog Sample Set (PSS) ID||Performance Source||Trait||
PGS Effect Sizes
(per SD change)
|PGS Classification Metrics||Other Metrics||Covariates Included in PGS Model||PGS Performance: Other Relevant Information|
|PPM000080||PGS000036 (gePS_T2D)||PSS000054||Udler MS et al. (2019) Ext.||Reported Trait: Type 2 diabetes||—||AUROC: 0.66||—||genotyping array, first 6 PCs of ancestry||—|
|PPM000081||PGS000036 (gePS_T2D)||PSS000054||Udler MS et al. (2019) Ext.||Reported Trait: Type 2 diabetes||—||AUROC: 0.73||—||age, sex, genotyping array, first 6 PCs of ancestry||—|
|PGS Catalog Sample Set (PSS) ID||Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases)||Sample Numbers||Sample Ancestry||Additional Ancestry Description||Cohort(s)||Additional Sample/Cohort Information|
|PSS000054||Prevalent T2D status was defined using self-reported medical history and medication||324,870 individuals
[ 13,480 cases, 311,390 controls]