PGS Publication: PGP000024

Publication Information (EuropePMC)
Title Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine.
PubMed ID 31322649(Europe PMC)
doi 10.1210/er.2019-00088
Publication Date Dec. 1, 2019
Journal Endocr Rev
Author(s) Udler MS, McCarthy MI, Florez JC, Mahajan A.
Released in PGS: Oct. 14, 2019

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000036 gePS_T2D PGP000023
Mahajan A et al. Nat Genet (2018)
Type 2 diabetes type II diabetes mellitus 171,249 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000036/ScoringFiles/PGS000036.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000080 PGS000036 (gePS_T2D) PSS000054 PGP000024
Udler MS et al. (2019)
Ext.
Reported Trait: Type 2 diabetes AUROC: 0.66 genotyping array, first 6 PCs of ancestry
PPM000081 PGS000036 (gePS_T2D) PSS000054 PGP000024
Udler MS et al. (2019)
Ext.
Reported Trait: Type 2 diabetes AUROC: 0.73 age, sex, genotyping array, first 6 PCs of ancestry

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000054 Prevalent T2D status was defined using self-reported medical history and medication
[
  • 13,480 cases
  • , 311,390 controls
]
European UKB