Publication: Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.

Information

PGS Catalog Publication (PGP) ID: PGP000025
PubMed ID: 24429243
doi: 10.1016/S2213-2600(13)70101-2

Publication Date: June 28, 2013

Journal: Lancet Respir Med

Authors: Belsky DW, Sears MR, Hancox RJ, Harrington H, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A.

PGS Associated with PGP000025

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000082 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Asthma onset, up to age 38 years HR: 1.12 [1.01 - 1.26] sex
PPM000083 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Life-course-persistent asthma RR: 1.36 [1.14 - 1.63] sex
PPM000084 PGS000037 (PGS_AST) PSS000056 Belsky DW et al. (2013) Reported Trait: Asthma onset HR: 1.17 [1.01 - 1.34] AUROC: 0.61 [0.53 - 0.7] sex
PPM000085 PGS000037 (PGS_AST) PSS000056 Belsky DW et al. (2013) Reported Trait: Life-course-persistent asthma RR: 1.2 [1.05 - 1.38] sex
PPM000086 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Atopy (skin test for common allergen 2mm > control) RR: 1.07 [1.01 - 1.14] sex
PPM000087 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Airway hyper-responsiveness to methacholine or albuterol RR: 1.16 [1.03 - 1.32] sex
PPM000088 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Incompletely reversible airflow obstruction (IRAO, post-bronchodilator FEV1:FVC more than 2SD below mean) RR: 1.28 [1.04 - 1.57] sex
PPM000089 PGS000037 (PGS_AST) PSS000055 Belsky DW et al. (2013) Reported Trait: Admitted to hospital for asthma RR: 1.38 [1.07 - 1.79] sex

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000055 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. 880 individuals
[ 305 cases, 575 controls]
51.00 %% Male samples
European DMHDS
PSS000056 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. 187 individuals European DMHDS Subset of children from DMHDS with asthma onset in childhood (before age 13 years)