PGS Publication: PGP000025

Publication Information (EuropePMC)
Title Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.
PubMed ID 24429243(Europe PMC)
doi 10.1016/S2213-2600(13)70101-2
Publication Date June 28, 2013
Journal Lancet Respir Med
Author(s) Belsky DW, Sears MR, Hancox RJ, Harrington H, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A.
Released in PGS: Dec. 18, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000037 PGS_AST PGP000025
Belsky DW et al. Lancet Respir Med (2013)
Asthma asthma 15 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000037/ScoringFiles/PGS000037.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000089 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Admitted to hospital for asthma RR: 1.38[1.07, 1.79] sex
PPM000088 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Incompletely reversible airflow obstruction (IRAO, post-bronchodilator FEV1:FVC more than 2SD below mean) RR: 1.28[1.04, 1.57] sex
PPM000087 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Airway hyper-responsiveness to methacholine or albuterol RR: 1.16[1.03, 1.32] sex
PPM000086 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Atopy (skin test for common allergen 2mm > control) RR: 1.07[1.01, 1.14] sex
PPM000085 PGS000037 (PGS_AST) PSS000056 PGP000025
Belsky DW et al. (2013)
Reported Trait: Life-course-persistent asthma RR: 1.2[1.05, 1.38] sex
PPM000084 PGS000037 (PGS_AST) PSS000056 PGP000025
Belsky DW et al. (2013)
Reported Trait: Asthma onset HR: 1.17[1.01, 1.34] AUROC: 0.61[0.53, 0.7] sex
PPM000083 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Life-course-persistent asthma RR: 1.36[1.14, 1.63] sex
PPM000082 PGS000037 (PGS_AST) PSS000055 PGP000025
Belsky DW et al. (2013)
Reported Trait: Asthma onset, up to age 38 years HR: 1.12[1.01, 1.26] sex

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000055 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. Median = 38.0 years
Range = [0.0, 38.0] years
[
  • 305 cases
  • , 575 controls
]
,
51.0 % Male samples
European DMHDS
PSS000056 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. 187 individuals European DMHDS Subset of children from DMHDS with asthma onset in childhood (before age 13 years)