Publication: Accurate and robust genomic prediction of celiac disease using statistical learning.

Information

PGS Catalog Publication (PGP) ID: PGP000028
PubMed ID: 24550740
doi: 10.1371/journal.pgen.1004137

Publication Date: Feb. 13, 2014

Journal: PLoS Genet

Authors: Abraham G, Tye-Din JA, Bhalala OG, Kowalczyk A, Zobel J, Inouye M.

PGS Associated with PGP000028

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000093 PGS000040 (GRS_CeD) PSS000059 Abraham G et al. (2014) Reported Trait: Coeliac disease AUROC: 0.9
PPM000094 PGS000040 (GRS_CeD) PSS000061 Abraham G et al. (2014) Reported Trait: Coeliac disease AUROC: 0.87
PPM000095 PGS000040 (GRS_CeD) PSS000062 Abraham G et al. (2014) Reported Trait: Coeliac disease AUROC: 0.86
PPM000096 PGS000040 (GRS_CeD) PSS000063 Abraham G et al. (2014) Reported Trait: Coeliac disease AUROC: 0.87
PPM000097 PGS000040 (GRS_CeD) PSS000060 Abraham G et al. (2014) Reported Trait: Coeliac disease AUROC: 0.87

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000059 2,476 individuals
[ 647 cases, 1,829 controls]
European
(Finnish)
FINRISK, Health 2000
PSS000060 10,304 individuals
[ 5,907 cases, 4,397 controls]
European
(British)
Immunochip
PSS000061 1,040 individuals
[ 497 cases, 543 controls]
European
(Italian)
PSS000062 1,649 individuals
[ 803 cases, 846 controls]
European
(Dutch)
PSS000063 2,200 individuals
[ 778 cases, 1,422 controls]
European
(British)