PGS Publication: PGP000028

Publication Information (EuropePMC)
Title Accurate and robust genomic prediction of celiac disease using statistical learning.
PubMed ID 24550740(Europe PMC)
doi 10.1371/journal.pgen.1004137
Publication Date Feb. 13, 2014
Journal PLoS Genet
Author(s) Abraham G, Tye-Din JA, Bhalala OG, Kowalczyk A, Zobel J, Inouye M.
Released in PGS: Dec. 18, 2019

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000040 GRS_CeD PGP000028
Abraham G et al. PLoS Genet (2014)
Coeliac disease celiac disease 228 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000040/ScoringFiles/PGS000040.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000097 PGS000040 (GRS_CeD) PSS000060 PGP000028
Abraham G et al. (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000096 PGS000040 (GRS_CeD) PSS000063 PGP000028
Abraham G et al. (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000095 PGS000040 (GRS_CeD) PSS000062 PGP000028
Abraham G et al. (2014)
Reported Trait: Coeliac disease AUROC: 0.86
PPM000094 PGS000040 (GRS_CeD) PSS000061 PGP000028
Abraham G et al. (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000093 PGS000040 (GRS_CeD) PSS000059 PGP000028
Abraham G et al. (2014)
Reported Trait: Coeliac disease AUROC: 0.9

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000059
[
  • 647 cases
  • , 1,829 controls
]
European
(Finnish)
FINRISK, Health 2000
PSS000060
[
  • 5,907 cases
  • , 4,397 controls
]
European
(British)
Immunochip
PSS000061
[
  • 497 cases
  • , 543 controls
]
European
(Italian)
PSS000062
[
  • 803 cases
  • , 846 controls
]
European
(Dutch)
PSS000063
[
  • 778 cases
  • , 1,422 controls
]
European
(British)