Publication: Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting.

Information

PGS Catalog Publication (PGP) ID: PGP000042
PubMed ID: 28223407
doi: 10.1161/CIRCULATIONAHA.116.024436

Publication Date: Feb. 21, 2017

Journal: Circulation

Authors: Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth A, Rader DJ, Ford I, Sattar N, Kathiresan S.

PGS Associated with PGP000042

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000144 PGS000057 (CHD57) PSS000091 Natarajan P et al. (2017) Reported Trait: Coronary heart disease (incident) HR (highest vs. lowest quintile of PGS): 1.66 [1.21 - 2.29] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000145 PGS000057 (CHD57) PSS000090 Natarajan P et al. (2017) Reported Trait: Coronary artery calcification OR: 1.32 [1.04 - 1.68] OR (highest vs. lowest quintile of PGS): 2.51 [1.08 - 5.85] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000146 PGS000057 (CHD57) PSS000089 Natarajan P et al. (2017) Reported Trait: Carotid artery plaque burden β: 1.097 [1.022 - 1.178] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000089 Total carotid plaque burden (mm2) 4,392 individuals BioImage
PSS000090 Total coronary arterial clacification (CAC) was coded as a a dichotomous outcome variable (CAC>0 versus CAC=0), and quantified by the Agatston method 1,154 individuals CARDIA
PSS000091 Nonfatal myocardial infarction or death from CHD 2,440 individuals
100.00 %% Male samples
Participants were all men hypercholesterolemia but without a history of myocardial infarction, allocated to the placebo group