Publication: Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial.

Information

PGS Catalog Publication (PGP) ID: PGP000043
PubMed ID: 30262460
doi: 10.2337/dc18-0709

Publication Date: Sept. 27, 2018

Journal: Diabetes Care

Authors: Morieri ML, Gao H, Pigeyre M, Shah HS, Sjaarda J, Mendonca C, Hastings T, Buranasupkajorn P, Motsinger-Reif AA, Rotroff DM, Sigal RJ, Marcovina SM, Kraft P, Buse JB, Wagner MJ, Gerstein HC, Mychaleckyj JC, Parè G, Doria A.

PGS Associated with PGP000043

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000147 PGS000058 (CAD_GRS_204) PSS000092 Morieri ML et al. (2018) Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.27 [1.18 - 1.37] age, sex, ACCORD study covariates (randomized treament assignement, clinical network, genotyping platform, PCs of genetic ancestry)
PPM000148 PGS000058 (CAD_GRS_204) PSS000093 Morieri ML et al. (2018) Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.35 [1.16 - 1.58] age, sex, ORIGIN study covariates (randomized treament assignement, PCs of genetic ancestry)

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000092 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina 5,360 individuals
[ 675 cases, 4,685 controls]
64.80 %% Male samples
European Self reported white ACCORD Type 2 Diabetes patients
PSS000093 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina 1,931 individuals
[ 163 cases, 1,768 controls]
European Self reported white ORIGIN Participants are from the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial and were enrolled based on having some combination of impaired fasting glucose, impaired glucose tolerance or type 2 diabetes, and high cardiovascular risk