Publication: Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial.
Publication Date: Sept. 27, 2018
Journal: Diabetes Care
Authors: Morieri ML, Gao H, Pigeyre M, Shah HS, Sjaarda J, Mendonca C, Hastings T, Buranasupkajorn P, Motsinger-Reif AA, Rotroff DM, Sigal RJ, Marcovina SM, Kraft P, Buse JB, Wagner MJ, Gerstein HC, Mychaleckyj JC, Parè G, Doria A.
PGS Associated with PGP000043
PGS Developed By This Study
PGS Performance MetricsDisclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|PGS Performance Metric (PPM) ID||Evaluated Score||PGS Catalog Sample Set (PSS) ID||Performance Source||Trait||
PGS Effect Sizes
(per SD change)
|PGS Classification Metrics||Other Metrics||Covariates Included in PGS Model||PGS Performance: Other Relevant Information|
|PPM000147||PGS000058 (CAD_GRS_204)||PSS000092||Morieri ML et al. (2018)||Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients||HR: 1.27 [1.18 - 1.37]||—||—||age, sex, ACCORD study covariates (randomized treament assignement, clinical network, genotyping platform, PCs of genetic ancestry)||—|
|PPM000148||PGS000058 (CAD_GRS_204)||PSS000093||Morieri ML et al. (2018)||Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients||HR: 1.35 [1.16 - 1.58]||—||—||age, sex, ORIGIN study covariates (randomized treament assignement, PCs of genetic ancestry)||—|
|PGS Catalog Sample Set (PSS) ID||Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases)||Sample Numbers||Sample Ancestry||Additional Ancestry Description||Cohort(s)||Additional Sample/Cohort Information|
|PSS000092||Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina||5,360 individuals
[ 675 cases, 4,685 controls]
64.80 %% Male samples
|European||Self reported white||ACCORD||Type 2 Diabetes patients|
|PSS000093||Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina||1,931 individuals
[ 163 cases, 1,768 controls]
|European||Self reported white||ORIGIN||Participants are from the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial and were enrolled based on having some combination of impaired fasting glucose, impaired glucose tolerance or type 2 diabetes, and high cardiovascular risk|